Articles Vol. 67 No. 10 31/10/2026

CLINICAL FEATURES AND SUBCLINICAL CHARACTERISTICS OF PATIENTS WITH OVERLAP SYNDROME OF OBSTRUCTIVE SLEEP APNEA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT THE NATIONAL LUNG HOSPITAL

Pham Hoang Trang, Nguyen Minh Sang, Dinh Van Luong
DOI: 10.52163/yhc.v67i10.6902
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Abstract

Objective: To describe the clinical and laboratory characteristics of patients with COPD-OSA overlap syndrome and to identify factors associated with obstructive sleep apnea (OSA) among patients with chronic obstructive pulmonary disease (COPD).

Materials and Methods: This cross-sectional descriptive study enrolled 85 patients with COPD–OSA overlap syndrome who underwent polysomnography at the Department of Sleep Medicine, National Lung Hospital, between January 2024 and December 2025.

Results: Among 85 patients with COPD–OSA overlap syndrome, the mean age was 68.5 ± 8.9 years. The majority of participants were male (89.4%). The mean body mass index (BMI) was 23.2 ± 2.9 kg/m² and the mean apnea–hypopnea index (AHI) was 30.4 ± 17.1 events/hour .The prevalence of hypertension and diabetes mellitus was 49.4% and 20.0% .Spearman correlation analysis showed that AHI had a moderate positive correlation with BMI (ρ = 0.431; p < 0.001). Chi-square analysis demonstrated a statistically significant association between hypertension and the severity of obstructive sleep apnea (p = 0.022).

Conclusion: Patients with COPD–OSA overlap syndrome in our study were predominantly older men, and most had moderate-to-severe obstructive sleep apnea. The apnea–hypopnea index (AHI) showed a moderate positive correlation with body mass index (BMI). Hypertension was significantly associated with the severity of obstructive sleep apnea.

Keywords
Chronic obstructive pulmonary disease (COPD); Obstructive sleep apnea (OSA); Polysomnography (PSG)
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