Articles Vol. 67 No. 10 31/10/2026

LOCALIZED BLADDER AMYLOIDOSIS MIMICKING BLADDER CANCER: A CASE REPORT

Dang Anh Phuong, Nguyen Thi Hong Van, Nguyen Phuong Hoa
DOI: 10.52163/yhc.v67i10.6901
21 Views
0 Downloads
Abstract

Background: Localized bladder amyloidosis is a rare condition characterized by extracellular deposition of amyloid proteins and may mimic bladder tumors because of its nonspecific clinical and imaging findings.

Case presentation: An 84-year-old woman presented with gross hematuria, oliguria, and fatigue. Laboratory investigations revealed severe anemia and advanced renal failure. Imaging demonstrated right hydronephrosis and ureteral dilatation, suggesting obstruction by a bladder mass.

Intervention and outcome: The patient underwent transurethral resection of the bladder lesion. Histopathological examination revealed amorphous eosinophilic deposits in the stroma. Congo red staining showed characteristic apple-green birefringence under polarized light, confirming localized bladder amyloidosis.

Conclusion: Localized bladder amyloidosis should be considered in the differential diagnosis of bladder masses presenting with hematuria. Histopathological examination, particularly Congo red staining, remains the gold standard for definitive diagnosis.

Keywords
Bladder amyloidosis, hematuria, bladder tumor mimic, Congo red, pathology.
References
[1]
[1] Merlini G. AL amyloidosis: from molecular mechanisms to targeted therapies. Hematology Am Soc Hematol Educ Program, 2017, 2017 (1): 1-12. doi: 10.1182/asheducation-2017.1.1 Google Scholar
[2]
[2] Yu Z.Y, Yan L, Wang H.K et al. Bladder triangle amyloidosis: a case report and literature review. Medicine (Baltimore), 2022, 101 (49): e32179. doi: 10.1097/MD.0000000000032179 Google Scholar
[3]
[3] Sipe J.D et al. Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification - International Society of Amyloidosis 2016 nomenclature guidelines. Amyloid - Int J Exp Clin Investig Off J Int Soc Amyloidosis, 2016, 23 (4): 209-213. doi: 10.1080/13506129.2016.1257986 Google Scholar
[4]
[4] Calvin S.H.Ng, Wan S, Yim A.P.C, Vale J. Idiopathic localised bladder amyloidosis: rare cause of haematuria. Int Urol Nephrol, 2002, 34 (1): 55-8. doi: 10.1023/a:1021302827755 Google Scholar
[5]
[5] Merlini G et al. Systemic immunoglobulin light chain amyloidosis. Nat Rev Dis Primer, 2018, 4 (1): 38. doi: 10.1038/s41572-018-0034-3 Google Scholar
[6]
[6] Jain M et al. Localized amyloidosis of urinary bladder: a diagnostic dilemma. Indian J Pathol Microbiol, 2008, 51 (2): 247-9. doi: 10.4103/0377-4929.41671 Google Scholar
[7]
[7] Pyrgidis N et al. Amyloidosis of the urinary bladder: a systematic review and a proposed management algorithm. Urology, 2021, 156: e12-e19. doi: 10.1016/j.urology.2021.07.013 Google Scholar