Articles Tập 67 Số CĐ15 25/09/2026

FUNCTIONAL CHARACTERISTICS OF LEFT VENTRICULAR DILATION IN NEWLY DETECTED OVERWEIGHT AND OBESE HYPERTENSIVE PATIENTS

Nguyen Thi Thanh Ha, Do Doan Loi, Do Kim Bang, Dinh Ngoc Son
DOI: 10.52163/yhc.v67iCD15.6823
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Abstract

Objectives: To describe left ventricular diastolic function and examine its association with body mass index and selected cardiovascular risk factors in newly diagnosed hypertensive patients with overweight or obesity.

Methods: This analytical cross-sectional study included 120 patients at the Vietnam National Heart Institute, Bach Mai Hospital. Diastolic function was assessed using Doppler echocardiography, tissue Doppler imaging, and left atrial strain, and classified according to the 2025 ASE algorithm. Skewed variables were reported as median and interquartile range. The association between BMI and left atrial reservoir strain (LARS) was evaluated using multivariable linear regression with HC3 robust standard errors.

Results: Mean age was 52.02 ± 9.63 years, and 56.7% were men. Left ventricular diastolic dysfunction was identified in 85/120 patients (70.8%; 95% CI, 62.2–78.2), including grade I in 51.7% and grade II in 19.2%; no grade III or indeterminate cases were present in the final analytical dataset. Mean LARS was 30.80 ± 7.82%. Patients with obesity had 3.24 percentage points lower LARS than those with overweight (95% CI, −6.03 to −0.45; p = 0.023). After adjustment for age, sex, blood pressure, glucose, and lipid levels, each 1-kg/m² increase in BMI was associated with a 0.577-percentage-point decrease in LARS (95% CI, −1.126 to −0.028; p = 0.040). Obesity was not significantly associated with the composite LVDD outcome (adjusted OR, 1.347; 95% CI, 0.592–3.066; p = 0.478).

Conclusions: In this selected single-center sample, LVDD was common and predominantly grade I. BMI was independently and inversely associated with left atrial reservoir function, but not with the composite LVDD classification. The cross-sectional findings do not establish causality or support universal screening.

Keywords
Left ventricular diastolic dysfunction; hypertension; overweight; obesity; left atrial strain.
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