Articles Tập 67 Số CĐ15 25/09/2026

LESION CHARACTERISTICS, RECONSTRUCTION TECHNIQUES AND FUNCTIONAL OUTCOMES OF LIMB SALVAGE SURGERY WITH LIQUID NITROGEN-TREATED RECYCLED BONE AUTOGRAFTS

Ngo Viet Nhuan, Do Phuoc Hung, Le Van Tho, Pham Thanh Nha, Nguyen Hoang Phu, Phan Ba Vu Dong
DOI: 10.52163/yhc.v67iCD15.6772
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Abstract

Objective: To describe lesion characteristics, reconstruction techniques and MSTS functional outcomes in patients undergoing limb salvage surgery with liquid nitrogen-treated recycled bone autografts.

Methods: This retrospective case series included 36 patients diagnosed with malignant or intermediate bone tumors or soft tissue sarcomas invading bone. All patients underwent wide resection and reconstruction with liquid nitrogen-treated recycled bone autografts at five centers in Ho Chi Minh City from April 2020 to February 2025. MSTS functional scores were assessed in patients who retained their limb at last follow-up.

Results: The cohort comprised 10 histological tumor types, with osteosarcoma subtypes accounted for 72.2%. Four unusual anatomic sites were identified: ulna, fibula, calcaneus and scapula. Osteoarticular reconstruction was the most frequent type (55.6%). Mean defect length was 15.9 ± 4.4 cm. Mean MSTS score among 28 limb-retaining patients was 80.0 ± 11.8% (median 85.0%) and 21 patients (75.0%) had good or excellent outcomes. Mean MSTS scores in the intercalary and osteoarticular groups were 85.9% and 79.2%, respectively; no statistically significant difference was detected (p = 0.137).

Conclusion: Liquid nitrogen-treated recycled bone autografts were applied to various bone tumors and soft tissue sarcomas invading bone at multiple anatomical sites. Among patients who retained their limbs, functional outcomes were generally favorable and consistent with the range reported in previous studies.

Keywords
recycled bone autograft; liquid nitrogen; limb salvage surgery
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