Articles Vol. 64 No. CD 5 -Nghiên cứu khoa học 24/07/2024

EFFECT OF SAMAN JOINT TABLETS ON STRENGTH, KNEE JOINT MORPHOLOGY ON OSTEOARTHRITIS MODEL WITH MONOSODIUM IODOACETATE

Nguyen Thanh Hoang Linh1,2, Nguyen Thi Phuong1,2, Doan Minh Thuy1,2
1 Vietnam University of Traditional Medicine
2 Học viện Y - Dược học cổ truyền Việt Nam
Corresponding author: doanminhthuyvn@yahoo.com
DOI: 10.52163/yhc.v64i4.677
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Keywords
SAMAN tablets, knee osteoarthritis, rat.
Abstract

Objectives: To evaluate the effect of SAMAN joint tablets on bearing capacity, and knee morphology
in a model of osteoarthritis induced by monosodium iodoacetate (MIA).
Method: 50 Wistar white rats, divided into 05 lots, 10 mice/lot: Physiological control group; 04 lots
(Model/Treatment 1/Treatment 2/Reference lot) caused osteoarthritis by MIA, after 1 week of MIA
injection to mice drinking distilled water/joint SAMAN dose 476mg/kg/day and 952mg/kg /day/
indomethacin.
Results: SAMAN joint tablets at doses of 476mg/kg/day and 952mg/kg/day had the effect of
increasing the distribution of weight tolerance of the hind legs (p < 0.001 and p < 0.01) compared
with the model lot; p < 0.001 compared to before drug use); Reduces inflammatory and degenerative
knee joint damage on HE-stained knee histopathology, reduces the score of knee osteoarthritis
histopathological damage (p < 0.01 compared to the model lot). These effects of SAMAN joint
tablets were comparable to those of indomethacin at a dose of 2mg/kg/day.
Conclusions: SAMAN joint tablets have analgesic, anti-inflammatory and anti-degenerative effects
on osteoarthritis models.

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