Objectives: Initial evaluation of the clinical improvement and safety of CDN granules in pediatric patients with non-organic enuresis
Patients and Methods: An observational study was conducted on 40 pediatric patients (aged 5-15 years) diagnosed with non-organic enuresis according to DSM-5 criteria, presenting with the Kidney Qi Deficiency pattern. Patients took CDN granules for 4 weeks and were followed up for 12 weeks to monitor enuresis frequency, Traditional Chinese Medicine symptoms, response rates, relapse rates, and safety indicators.
Results: The mean age was 7.98 ± 2.34 years, with a male-to-female ratio of 1.35:1. After 4 weeks of treatment, the mean enuresis frequency decreased from 5.35 ± 1.89 to 2.87 ± 1.54 /week (p<0,05). The rate of good and fair response reached 75%. At 4 and 8 weeks post-treatment, the good and fair response rates showed a downward trend. TCM symptoms (deep sleep with difficulty waking up, fatigue, aversion to cold, and cold extremities) all showed a tendency to improve. (p<0,05). No clinical adverse effects were recorded; changes in hematological parameters as well as liver and kidney functions were not statistically significant (p>0,05).
Conclusions: Initial research results of CDN granules show a positive signal in reducing enuresis frequency in a small-scale before-and-after study. Randomized controlled trials with longer treatment durations are needed to confirm its efficacy and safety.