Objective: To determine the readiness of mothers/caregivers of children under 1 year of age to accept childhood pneumococcal vaccination within the Expanded Programme on Immunization (EPI) and to identify factors associated with their readiness.
Methods: A cross-sectional study was conducted among 455 mothers or primary caregivers of children under 1 year of age in Thai Nguyen, Da Nang, and Can Tho, Vietnam, in 2026. Data were collected using a structured questionnaire and analyzed using multivariable logistic regression to identify factors associated with vaccination readiness.
Results: Overall, 402/455 (88.4%) of participants were willing to have their children receive pneumococcal vaccination through the EPI, with a mean readiness score of 9.2 ± 1.7 on a 10-point scale. Multivariable logistic regression showed that living in urban areas, receiving information about pneumococcal disease and vaccination from healthcare workers, and having a positive attitude toward pneumococcal disease and vaccination were independently associated with higher readiness to accept pneumococcal vaccination for children.
Conclusions: Mothers/caregivers of children under 1 year of age demonstrated a high level of readiness to accept the introduction of pneumococcal vaccination into Vietnam's Expanded Programme on Immunization. The findings suggest that strengthening communication through healthcare workers and promoting positive attitudes toward pneumococcal vaccination, particularly in rural areas, may further improve vaccine acceptance following its inclusion in the Programme.