Articles Vol. 67 No. 9 25/09/2026

SO SÁNH CHỈ SỐ ĐỊNH LƯỢNG THỂ TÍCH HỒI HẢI MÃ VÀ THANG ĐIỂM BÁN ĐỊNH LƯỢNG TEO THÙY THÁI DƯƠNG TRONG TRÊN CỘNG HƯỞNG TỪ Ở BỆNH NHÂN SA SÚT TRÍ TUỆ

Chu Duc Anh, Nguyen Thi Van Anh, Pham Ngco Lan, Hoang Dinh Au
DOI: 10.52163/yhc.v67i9.6633
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Abstract

Objective: To investigate the association between hippocampal volumetry on MRI and cognitive impairment as well as medial temporal atrophy (MTA) score, and to preliminarily compare quantitative (hippocampal volumetry) and semi-quantitative (MTA scoring) approaches in the assessment of dementia. Materials and Methods: This cross-sectional study included 20 patients with clinically diagnosed dementia at a tertiary geriatric hospital between December 2025 and April 2026. Cognitive status was assessed using the Mini-Mental State Examination (MMSE). MRI was performed on a 1.5T system using standardized 3D T1-weighted isotropic sequences (1 mm³ voxel). Hippocampal volumes were measured using manual segmentation on both hemispheres. MTA scores were independently rated. Statistical analysis included Mann–Whitney U test and Spearman correlation, with p < 0.05 considered statistically significant. Results: The mean age was 69.40 ± 5.84 years and mean MMSE score was 21.10 ± 4.06. Patients with higher MTA scores (≥2) showed lower hippocampal volumes compared with those with lower MTA scores (0–1) on both sides and in total volume (left: 2.50 ± 0.17 vs 2.92 ± 0.14; right: 2.63 ± 0.20 vs 2.93 ± 0.09; total: 5.14 ± 0.36 vs 5.84 ± 0.22), although differences were not statistically significant (p > 0.05). No significant correlation was observed between hippocampal volume and MMSE score (r = 0.18, p = 0.44). A moderate inverse trend was observed between hippocampal volume and MTA score (r = −0.41, p = 0.07).

Conclusion: Hippocampal volume showed a decreasing trend with increasing medial temporal atrophy and demonstrated a consistent trend with MTA scoring. MRI-based hippocampal volumetry represents a potential quantitative measure that may complement semi-quantitative MTA assessment. However, findings were not statistically significant and require validation in larger studies.

Keywords
dementia; hippocampus; magnetic resonance imaging; hippocampal volume; MTA; MMSE.
References
[1]
1. Naheed A, Hakim M, Islam MS, Islam MB, Tang EYH, Prodhan AA, et al. Prevalence of dementia among older age people and variation across different sociodemographic characteristics: a cross-sectional study in Bangladesh. Lancet Reg Health Southeast Asia. 2023;17:100257. doi:10.1016/j.lansea.2023.100257. Google Scholar
[2]
2. Xiao Y, Hu Y, Huang K, Alzheimer’s Disease Neuroimaging Initiative. Atrophy of hippocampal subfields relates to memory decline during the pathological progression of Alzheimer’s disease. Front Aging Neurosci. 2023;15:1287122. doi:10.3389/fnagi.2023.1287122. Google Scholar
[3]
3. Berron D, Vogel JW, Insel PS, Pereira JB, Xie L, Wisse LEM, et al. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain. 2021;144(9):2771–2783. doi:10.1093/brain/awab114. Google Scholar
[4]
4. Wittens MMJ, Allemeersch GJ, Sima DM, Vanderhasselt T, Raeymaeckers S, Fransen E, et al. Towards validation in clinical routine: a comparative analysis of visual MTA ratings versus the automated ratio between inferior lateral ventricle and hippocampal volumes in Alzheimer’s disease diagnosis. Neuroradiology. 2024;66:487–506. doi:10.1007/s00234-024-03280-8. Google Scholar
[5]
5. Hari I, Adeyemi OF, Gowland P, Bowtell R, Mougin O, Vesey P, et al. Memory impairment in Amyloid-β status Alzheimer’s disease is associated with a reduction in CA1 and dentate gyrus volume: in vivo MRI at 7T. Neuroimage. 2024;292:120607. doi:10.1016/j.neuroimage.2024.120607. Google Scholar
[6]
6. Mak E, Gabel S, Su L, Williams GB, Arnold R, Passamonti L, et al. Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer’s disease, and dementia with Lewy bodies. Int Psychogeriatr. 2017;29(4):545–555. doi:10.1017/S1041610216002143. Google Scholar
[7]
7. Garrafiel FN, Vidaletti VV, Soder RB, Paganin RP, da Silva MRA, Aguzzoli CS, et al. Association between hippocampal volume and visual classification of hippocampal atrophy: an MRI study. Alzheimers Dement. 2024;20:e091516. doi:10.1002/alz.091516. Google Scholar
[8]
8. Hale JM, Schneider DC, Mehta NK, Myrskylä M. Cognitive impairment in the U.S.: Lifetime risk, age at onset, and years impaired. SSM - Population Health. 2020;11:100577. doi:10.1016/j.ssmph.2020.100577 Google Scholar
[9]
9. Rosende-Roca M, García-Gutiérrez F, Cantero-Fortiz Y, Alegret M, Pytel V, Cañabate P, et al. Exploring sex differences in Alzheimer’s disease: a comprehensive analysis of a large patient cohort from a memory unit. Alzheimers Res Ther. 2025;17:27. doi:10.1186/s13195-024-01656-9. Google Scholar
[10]
10. Monfared AAT, Hummel N, Chandak A, Khachatryan A, Zhang R, Zhang Q. Prevalence Estimation of Dementia/Alzheimer’s Disease Using Health and Retirement Study Database in the United States. The Journal of Prevention of Alzheimer’s Disease. 2024;11:1183–8. doi:10.14283/jpad.2024.114 Google Scholar