FACTORS ASSOCIATED WITH MORTALITY IN CRITICALLY ILL COVID-19 PATIENTS INDICATED FOR OXIRIS HEMOADSORPTION

Objectives: To investigate factors associated with mortality in critically ill COVID-19 patients indicated for oXiris hemoadsorption. Methods: A retrospective observational cohort study was conducted on 1065 critically ill COVID-19 patients admitted to the Intensive Care Unit of the National Hospital for Tropical Diseases between March 2020 and October 2023. Multivariate logistic regression was utilized to identify independent factors associated with in-hospital mortality. Results: The in-hospital mortality rate was 31.1% (331/1065). Independent factors associated with mortality included age > 60 years (aOR = 2.970; p < 0.001), admission SOFA score (aOR = 1.118; p = 0.002), invasive mechanical ventilation (aOR = 2.436; p < 0.001), ECMO (aOR = 3.923; p = 0.009), acute kidney injury (aOR = 2.127; p < 0.001), lymphocyte count < 1 G/L (aOR = 2.091; p < 0.001), D-dimer > 5000 ng/mL (aOR = 1.792; p = 0.011), CRP ≥ 75 mg/L (aOR = 1.559; p = 0.016), and high-dose corticosteroid use (aOR = 1.785; p = 0.010). Pregnancy and Remdesivir treatment were associated with a decreased risk of mortality. Conclusion: Mortality in COVID-19 patients indicated for oXiris hemoadsorption is primarily associated with advanced age, multi-organ failure, severe respiratory failure, acute kidney injury, and severe inflammatory/coagulation disorders.