Articles Vol. 64 No. 3 24/04/2023

25. THE SUSCEPTIBILITY OF STREPTOCOCCUS PNEUMONIAE TO ANTIBIOTICS AMONG CHILDREN TREATED AT THE NATIONAL CHILDREN’S HOSPITAL, 2020

Nguyen Quang Thieu1,2, Hoang Dinh Canh1,2
1 National Institute of Malariology, Parasitology and Entomology
2 Viện Sốt rét-Ký sinh trùng-Côn trùng Trung ương
Corresponding author: thieunq@yahoo.com
DOI: 10.52163/yhc.v64i3.661
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Keywords
Streptococcus, pneumoniae, children,MIC: minimum Inhibitory Concentration.
Abstract

Objectives: Streptococcus pneumoniae causes severe diseases with a high mortality rate. The study
aims to determine the susceptibility of Streptococcus pneumoniae to antibiotics among children aged
< 5 years old at the National Children’s Hospital to find the most effective treatment.
Study methods: The study was conducted in the laboratory with a descriptive research design.
Results: Streptococcus was resistant to macrolides (> 95%), cotrimoxazole (90%), and clindamycin
(95.3%). Multiple antibiotic resistance Streptococcus accounted for 64%. In addition, 100% of
Streptococcus were sensitive to rifampicin, linezolid and vancomycin, followed by amoxicillin
(MIC90 = 2 µg/ml) at 95%, ceftriaxone (MIC90 = 4 µg/ml) at 61.1%, cefotaxime (MIC90 = 4 µg/ml) at
57.4%, and penicillin G (MIC90=4 µg/ml) at 43.9%.
Conclusions: Streptococcus was resistant to penicillins, cephalosporins, sulphonamides, and
macrolides. It was still sensitive to rifampin, glycopeptides, oxazolidinones, and quinolones.
Therefore, the treatment of Streptococcus pneumoniae should be based on its antibiotic resistance
patterns to find the most sensitive antibiotic.

References
[1]
Wahl B, Osbrien KM, Greenbaum A et al., Burden Google Scholar
[2]
of Streptococcus pneumoniae and Haemophilus Google Scholar
[3]
influenzae type b disease in children in India: Google Scholar
[4]
modelled estimates for 2000-15., The lancet Glob Google Scholar
[5]
Health, Vol.7(6), pp.735-747, 2018. Google Scholar
[6]
Viện Sốt rét - Ký sinh trùng - Côn trùng Trung Google Scholar
[7]
ương, Phương pháp nghiên cứu khoa học, Sách Google Scholar
[8]
đào tạo sau đại học, Nhà Xuất bản Y học, 2018. Google Scholar
[9]
Song JH, Jung SI, Ko KS et al., High prevalence Google Scholar
[10]
of antimicrobial resistance among clinical Google Scholar
[11]
Streptococcus pneumoniae isolates in Asia (an Google Scholar
[12]
ANSORP study). Antimicrob Agents Chemother, Google Scholar
[13]
(6), 2101-2107, 2004. Google Scholar
[14]
Van PH, Binh PT, Minh NH et al., Results from Google Scholar
[15]
the Survey of Antibiotic Resistance (SOAR) Google Scholar
[16]
-11 in Vietnam. J Antimicrob Chemother, 71 Google Scholar
[17]
Suppl 1 (Suppl 1), i93-102, 2016. Google Scholar
[18]
Torumkuney D, Van PH, Thinh LQ et al., Results Google Scholar
[19]
from the Survey of Antibiotic Resistance (SOAR) Google Scholar
[20]
-18 in Vietnam, Cambodia, Singapore and the Google Scholar
[21]
Philippines: data based on CLSI, EUCAST (dosespecific) Google Scholar
[22]
and pharmacokinetic/pharmacodynamic Google Scholar
[23]
(PK/PD) breakpoints. J Antimicrob Chemother, Google Scholar
[24]
(Suppl 1), i19-i42, 2020. Google Scholar
[25]
Hoa NQ, Trung NV, Larsson M et al., Decreased Google Scholar
[26]
Streptococcus pneumoniae susceptibility to oral Google Scholar
[27]
antibiotics among children in rural Vietnam: a Google Scholar
[28]
community study. BMC Infect Dis, 10 (85), Google Scholar
[29]
-11, 2010. Google Scholar
[30]
Larsson M, Nguyen HQ, Olson L et al., Google Scholar
[31]
Multidrug resistance in Streptococcus pneumoniae Google Scholar
[32]
among children in rural Vietnam more than Google Scholar
[33]
doubled from 1999 to 2014. Acta Paediatr, 111 Google Scholar
[34]
(6), 1916-1923, 2021. Google Scholar
[35]
Wang CY, Chen YH, Fang C et al., Antibiotic Google Scholar
[36]
resistance profiles and multidrug resistance Google Scholar
[37]
patterns of Streptococcus pneumoniae in Google Scholar
[38]
pediatrics: A multicenter retrospective study in Google Scholar
[39]
mainland China. Medicine (Baltimore), 98(24), Google Scholar
[40]
e15942, 2019. Google Scholar
[41]
Kim SH, Song JH, Chung DR et al., Changing Google Scholar
[42]
trends in antimicrobial resistance and serotypes Google Scholar
[43]
of Streptococcus pneumoniae isolates in Asian Google Scholar
[44]
countries: an Asian Network for Surveillance Google Scholar
[45]
of Resistant Pathogens (ANSORP) study. Google Scholar
[46]
Antimicrob Agents Chemother, 56 (3), 1418- Google Scholar
[47]
, 2012. Google Scholar
[48]
Batah Jameed and Vanron Emmanuenlle, Rappor Google Scholar
[49]
dactivite 2020, Epidemiologie 2018 -2019, Centre Google Scholar
[50]
National de Reference des Pneumocoques, Crteil. Google Scholar
[51]
pp1-80, 2020. Google Scholar