Articles Tập 67 Số CĐ14-HNKH Hội Hóa sinh Y học Việt Nam 17/09/2026

INITIAL EVALUATION OF PLASMA EXCHANGE OUTCOMES AND SAFETY IN HYPERTRIGLYCERIDEMIA-INDUCED ACUTE PANCREATITIS AT MILITARY HOSPITAL 175

Mai Dinh Thanh, Do Thanh Tung, Pham Thi Thao
DOI: 10.52163/yhc.v67iCD14.6587
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Abstract

Objective: To evaluate the outcomes and safety of plasma exchange (TPE) in patients with hypertriglyceridemia-induced acute pancreatitis (HTG-AP).

Subjects and methods: A descriptive study of a case series on HTG-AP patients with indication for TPE (ASFA 2019), treated with TPE, and compared with an insulin infusion group at Military Hospital 175.

Results: The median time from admission to TPE was 9 hours. Most patients (93,1%) required only one session, with 5% Albumin as the primary replacement fluid (96,6%). Median TG levels dropped significantly from 52 mmol/L to 5,5 mmol/L (88,6% reduction, p < 0,001) after one session. TPE also reduced Lipase levels (by 50%), and corrected pseudohyponatremia. After 24 hours, the TPE group had significantly lower TG levels than the ITTM group (5,5 vs 15,2 mmol/L, p < 0,001). The most common complications were thrombocytopenia (96,6%), hypokalemia (62,1%), and hypocalcemia (48,3%), all of which were well-managed. The discharge rate reached 100%, the median of hospital stay was 6,0 days, with no significant difference in both groups (p > 0,05).

Conclusion: Plasma exchange is a safe and highly effective method for rapid triglyceride reduction and homeostasis correction in severe HTG-AP patients within the first 24 hours.

Keywords
Acute pancreatitis, hypertriglyceridemia, plasma exchange, 5% albumin.
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