Objectives: To evaluate the results of first-trimester preeclampsia screening using a combined model with PLGF and to describe the clinical and paraclinical characteristics of high-risk pregnant women.
Subjects and methods: A cross-sectional descriptive study was conducted on 52 pregnant women with singleton pregnancies between 11 weeks and 13 weeks 6 days of gestation, screened at Thai Nguyen A Hospital (from March to October 2025). Preeclampsia risk was determined using the FMF algorithm. Data were analyzed using SPSS 26.0 software.
Results: 17.3% of pregnant women were classified into the high-risk preeclampsia group. The high-risk group had significantly higher blood pressure and a higher rate of positive proteinuria compared to the low-risk group (p < 0.05). PLGF levels in the high-risk group tended to be lower than in the low-risk group; however, this difference was not statistically significant. All high-risk cases were predicted to have a risk of preeclampsia before 37 weeks of gestation, with 66.7% having a risk of onset before 34 weeks.
Conclusions: The first-trimester preeclampsia screening model according to the FMF algorithm using the PLGF marker showed that 17.3% of pregnant women were classified as high-risk, all of whom were at risk for preeclampsia before 37 weeks. The high-risk group had significantly higher mean blood pressure and positive proteinuria rates, while PLGF levels showed a decreasing trend but did not reach statistical significance compared to the low-risk group.