Articles Tập 67 Số CĐ14-HNKH Hội Hóa sinh Y học Việt Nam 19/09/2026

ASSOCIATION BETWEEN THE HBA1C/HDL-C RATIO AND CARDIOMETABOLIC MULTIMORBIDITY AMONG ADULTS AGED 45 YEARS AND OLDER

Nguyen Thi Linh Hoa, Nguyen Thi Huong, Nguyen Thanh Hien, Le Nguyen Minh Phuong, Do Quoc Trung, Nguyen Thi Thuy, Vu Thanh Trung, Pham Thien Ngoc
DOI: 10.52163/yhc.v67iCD14.6476
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Abstract

Objective: To evaluate the association between the HbA1c/HDL-C ratio and cardiovascular-metabolic multimorbidity (CMM) among patients aged 45 years and older at Phenikaa University Hospital.

Methods: A cross-sectional descriptive study was conducted on 1,502 patients aged 45 years and older at Phenikaa University Hospital from March 2026 to June 2026.

Results: The prevalence of CMM in the study sample was 29.7%. When the HbA1c/HDL-C ratio was analyzed as a continuous variable and divided into quartiles (Q1–Q4), the prevalence of CMM progressively increased from 13.3% in Q1 to 50.3% in Q4. In the multivariable model, the Q4 group had a 4.77-fold higher likelihood of having CMM compared to the Q1 group (aOR = 4.77; 95% CI: 3.25–7.01), with a p-trend < 0.001. When analyzed as a continuous variable, each unit increase in the HbA1c/HDL-C ratio was associated with a higher likelihood of CMM (aOR = 1.31; 95% CI: 1.21–1.41).

Conclusion: A high HbA1c/HDL-C ratio is independently associated with CMM in patients aged 45 years and older. The HbA1c/HDL-C ratio holds potential as a simple biomarker reflecting the burden of cardiovascular-metabolic diseases; however, prospective studies are needed to evaluate its predictive value.

Keywords
HbA1c/HDL-C ratio, CMM, HbA1c, HDL-C
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