Articles Tập 67 Số CĐ14-HNKH Hội Hóa sinh Y học Việt Nam 19/09/2026

PLASMA ESTRADIOL, TESTOSTERONE, AND SEX HORMONE-BINDING GLOBULIN CONCENTRATIONS, FREE ANDROGEN INDEX, AND THEIR ASSOCIATIONS WITH METABOLIC SYNDROME IN PERIMENOPAUSAL AND POSTMENOPAUSAL FEMALE HEALTHCARE WORKERS

Tran Thanh Duong, Nguyen Thi Diep Anh, Nguyen Thi Trinh, Bui Thi Thu Huong
DOI: 10.52163/yhc.v67iCD14.6475
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Abstract

Objectives: To analyze the association between serum levels of estradiol, testosterone, SHBG, and the free androgen index (FAI) with metabolic syndrome (MetS) in perimenopausal and menopausal female healthcare workers.

Subjects and methods: A cross-sectional descriptive study was conducted on 231 perimenopausal-menopausal female healthcare workers aged 45-55, currently working at several health facilities in Hanoi and Thai Nguyen province, from January 2025 to April 2026.

Results: The MetS group had significantly higher testosterone and FAI levels than the non-MetS group with geometric means of 0.27 nmol/L versus 0.19 nmol/L (p = 0.025) and 0.64 versus 0.36 (p < 0.001), respectively. Conversely, SHBG levels were significantly lower in the MetS group compared with the non-MetS group, with geometric means of 41.27 nmol/L and 54.04 nmol/L, respectively (p < 0.001). SHBG levels tended to decrease, while FAI tended to increase, with an increasing number of MetS diagnostic criteria (p=0,001 and p=0,002, respectively).

Conclusion: SHBG and FAI are two endocrine factors significantly and consistently associated with MetS, and may serve as reference markers for assessing the presence and severity of MetS in perimenopausal-menopausal female healthcare workers.

Keywords
Metabolic syndrome, sex hormones, female healthcare workers, perimenopause-menopause.
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