Articles Tập 67 Số CĐ14-HNKH Hội Hóa sinh Y học Việt Nam 19/09/2026

HYPOPHOSPHATEMIA IN MECHANICALLY VENTILATED PATIENTS WITH RESPIRATORY FAILURE AT THE INTENSIVE CARE AND POISON CONTROL DEPARTMENT, SAINT PAUL GENERAL HOSPITAL.

Vu Thi Thuy Trang, Hoang Thu Ha, Ta Van Thao
DOI: 10.52163/yhc.v67iCD14.6460
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Abstract

Objectives: To investigate the characteristics of hypophosphatemia and evaluate the relationship between phosphorus levels and electrolyte disturbances, duration of mechanical ventilation, weaning outcomes, and mortality in patients undergoing invasive mechanical ventilation.

Subjects and Methods: A descriptive, prospective study was conducted on emergency and intensive care patients undergoing mechanical ventilation from July 2025 to March 2026. Data were collected on phosphorus levels, electrolytes, clinical characteristics, duration of mechanical ventilation, weaning failure, and mortality over 28 days.

Results: among 130 patients included in the study, the prevalence of hypophosphatemia was 23.1% within the first 24 hours of ICU admission. The rate of hypophosphatemia during mechanical ventilation was 51.7%. The hypophosphatemic group had lower potassium and magnesium levels than the non-hyponatrophic group (p = 0.003 and p = 0.004). Phosphorus levels correlated positively with potassium (rs = 0.354; p < 0.001) and magnesium (rs = 0.389; p < 0.001), but not with calcium and sodium. The duration of mechanical ventilation was longer in the hypophosphatemic group (200 hours vs. 146.5 hours), but the difference was not statistically significant. Hypophosphatemia was not significantly associated with weaning failure, duration of resuscitation, or mortality.

Conclusion: Hypophosphatemia is a common electrolyte disorder in critically ill patients on mechanical ventilation. Low phosphorus levels are often accompanied by hypokalemia and hypomagnesemia, suggesting the need for simultaneous monitoring of these electrolytes in the management of critically ill patients.

Keywords
Hypophosphatemia; critically ill patients; intensive care unit; mechanical ventilation.
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