Articles Tập 67 Số CĐ14-HNKH Hội Hóa sinh Y học Việt Nam 19/09/2026

PREVALENCE OF VITAMIN D DEFICIENCY AND CORRELATIONS BETWEEN PLASMA 25-HYDROXYVITAMIN D CONCENTRATIONS AND SELECTED BIOCHEMICAL PARAMETERS OF BONE METABOLISM AMONG FEMALE HEALTHCARE WORKERS AGED 45–55 YEARS

Nguyen Thi Diep Anh, Tran Thanh Duong, Vu Thi Huyen Trang, Tran Khanh Chi, Pham Thi Duc Hanh, Pham Ngoc Thien
DOI: 10.52163/yhc.v67iCD14.6459
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Abstract

Objectives: To determine the prevalence of vitamin D deficiency and its correlation with serum ionized calcium, phosphorus, and parathyroid hormone (PTH) levels among female healthcare workers aged 45-55 years.

Subjects and Methods: A cross-sectional descriptive study was conducted on 406 female healthcare workers aged 45-55, currently working at several health facilities in inner Hanoi and in Thai Nguyen province. The study was carried out from January 2025 to April 2026.

Results: Using a cut-off value of <30 ng/mL, the proportions of participants with low and adequate Vit.D levels were 79.8% and 20.2%, respectively. When a cut-off value of <20 ng/mL was applied, the corresponding proportions were 19.7% and 80.3%. The mean levels of vitamin D, ionized calcium, phosphorus, and PTH were 26,04 ± 7,14 ng/mL, 1,15 ± 0,10 mmol/L, 0,95 ± 0,17 mmol/L, and 3,74 ± 1,79 pmol/L, respectively. There was a statistically significant difference in ionized calcium levels between the vitamin D-deficient and vitamin D-sufficient groups at both cut-off values of 20 ng/mL and 30 ng/mL (p<0.001 for both comparisons), while no significant differences were found for phosphorus and PTH (p>0,05). Vitamin D was positively correlated with ionized calcium (rho=0,280; p<0,001), and weakly positively correlated with phospho (rho=0,115; p=0,022) and age (rho=0,114; p=0,023). No significant correlation was found between Vit.D and PTH levels.

Conclusion: Among female healthcare workers aged 45–55 years, 79.8% had Vit.D levels below 30 ng/mL, including 19.7% with Vit.D deficiency below 20 ng/mL. Vitamin D levels showed weak positive correlations with ionized calcium, phosphate, and age, with the correlation with ionized calcium being stronger than those with the other factors.

Keywords
vitamin D, ionized calcium, phosphorus, parathyroid hormone (PTH), female healthcare workers aged 45-55.
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