To evaluate changes in serum 25 (OH)D levels following treatment for vitamin D deficiency in pregnant women and to assess the association between vitamin D deficiency and adverse pregnancy outcomes. A pre-post intervention study combinded with a descriptive study was conducted in 252 pregnant women diagnosed with vitamin D deficiency. All participants received treatment for vitamin D deficiency and were followed until delivery at Hai Phong Obstetrics and Gynecology Hospital, Vietnam, between 2024 and 2025. The mean 25(OH)D concentration before treatment was 49.01 ± 11.01 nmol/L, and after treatment, the mean concentration was 75.80 ± 13.12 nmol/L. After treatment, 25(OH)D concentrations increased significantly in both the severe and moderate deficiency groups compared to before treatment. A factor associated with the change in vitamin D concentration during treatment was treatment adherence. Pregnant women with 25(OH)D deficiency who adhered to treatment had a reduced rate of gestational diabetes and cesarean section. Following vitamin D supplementation, 25(OH)D levels increased significantly, and the rate of achieving normal levels improved considerably. The study also noted that 25(OH)D deficiency was associated with several adverse pregnancy outcomes. This suggests that screening and treating vitamin D deficiency during pregnancy is essential for improving the health of both the mother and the fetus.
CHANGES IN SERUM 25 – HYDROXYVITAMIN D [25(OH)D] LEVELS FOLLOWING TREATMENTFOR VITAMIN D DEFICIENCY IN PREGNANT WOMEN AT HAI PHONG OBSTETRICS AND GYNECOLOGY HOSPITAL, FROM 2024 TO 2025
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Abstract
Keywords
Supplement with vitamin D, 25(OH)D, pregnancy.
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