Articles Tập 67 Số CĐ14-HNKH Hội Hóa sinh Y học Việt Nam 19/09/2026

ASSOCIATION OF TSH LEVELS WITH DYSLIPIDEMIA AND LIVER ENZYMES IN PATIENTS WITH NEWLY DIAGNOSED PRIMARY HYPOTHYROIDISM AT VINH PHUC GENERAL HOSPITAL

Nguyen Thi Van1,2, Luu Vu Dung3,4, Pham Thi Thu Trang3,4
1 Vinh Phuc General Hospital
2 Bệnh viện Đa khoa Vĩnh Phúc
3 Hai Phong University of Medicine and Pharmacy
4 Trường Đại học Y dược Hải Phòng
DOI: 10.52163/yhc.v67iCD14.6454
0 Views
0 Downloads
Abstract

Background & Objective: Elevated TSH in hypothyroidism was a risk factor for dyslipidemia and hepatocellular injury. This study aimed to investigate the lipid profile, liver enzymes, and their independent associations with TSH in patients with newly diagnosed hypothyroidism. 

Methods: A cross-sectional study included 171 patients at Vinh Phuc General Hospital (01/2025–03/2026). Multivariable linear regression was utilized to adjust for age, gender, and

BMI. 

Results: The mean age was 56.8 ± 16.9 years; 77.8% were female, and 87.7% had subclinical hypothyroidism. Dyslipidemia prevalence was 67.3%. Overt hypothyroid patients had significantly higher LDL-C and total cholesterol than subclinical patients (p < 0.05). TSH positively correlated with AST (r = 0.258) and ALT (r = 0.243). In the subgroup with TSH ≥ 10 mIU/L, TSH significantly correlated with LDL-C (r = 0.331; 95% CI: 0.034 - 0.574; p = 0.030). Multivariable regression confirmed TSH as an independent predictor of elevated LDL-C (unstandardized β = 0.007; 95% CI: 0.001 - 0.013; p = 0.009). 

Conclusion: Newly diagnosed primary hypothyroid patients exhibited a high dyslipidemia rate. TSH independently predicted increased LDL-C and correlated with hepatocellular injury. 

Keywords
Primary hypothyroidism, TSH, LDL-C, liver enzymes.
References
[1]
[1] Jonklaas J. Hypothyroidism, lipids, and lipidomics. Endocrine. 2024; 84 (2): 293 - 300. Google Scholar
[2]
[2] Yorke E. Co-Morbid Hypothyroidism and Liver Dysfunction: A Review. Clinical Med Insights: Endocrinol and Diabetes. 2024; 17: 1 - 6. Google Scholar
[3]
[3] Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012; 18 (6): 988 - 1028. Google Scholar
[4]
[4] Usman M, Bilal M, Hussain T, et al. Pattern of lipid abnormalities in newly diagnosed primary hypothyroidism: a cross-sectional study from Nowshera, Pakistan. J Bahria Univ Med Dent Coll. 2026; 16 (3): 756 - 761. Google Scholar
[5]
[5] Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001; 285 (19): 2486 - 2497. Google Scholar
[6]
[6] Trương Thanh Hương, Châu Ngọc Hoa, Phạm Mạnh Hùng, et al. Khuyến cáo về chẩn đoán và điều trị rối loạn lipid máu. Khuyến cáo về các bệnh lý tim mạch và chuyển hóa (Hội Tim mạch học Quốc gia Việt Nam). Nhà xuất bản Y học. 2015: 1 - 45. Google Scholar
[7]
[7] Trần Thị Bích Liên, Nguyễn Khoa Diệu Vân. Nhận xét đặc điểm lâm sàng, cận lâm sàng của bệnh nhân viêm tuyến giáp mạn tính Hashimoto. Tạp chí y học Việt Nam. 2024; 540 (2): 270 - 275. Google Scholar
[8]
[8] Ni W, Zhang M, Wang X, et al. Age-specific serum thyrotropin reference range for the diagnosis of subclinical hypothyroidism and its association with lipid profiles in the elderly population. Sci Rep. 2022; 12: 20872. Google Scholar
[9]
[9] Mawlood MS. The unseen impact of subclinical hypothyroidism on lipid profile and cardiovascular risk. Biochem Biophys Rep. 2026; 46: 102605. Google Scholar
[10]
[10] Wang P, Zhang W, Liu H. Research status of subclinical hypothyroidism promoting the development and progression of cardiovascular diseases. Front Cardiovasc Med. 2025;12:1527271. doi:10.3389/fcvm.2025.1527271. Google Scholar