Articles Vol. 64 No. 3 24/04/2023

9. STUDY ON EFFECTIVENESS OF ANTI-INFLAMMATORY, ANTI-MICROBIAL OF COLD PLASMA IN PATIENTS WITH INFECTIOUS WOUND

Do Dinh Tung1,2, Do Hoang Tung3,4
1 Saint Paul General Hospital
2 Bệnh viện Đa Khoa Xanh Pôn
3 Institute of Physics, Vietnam Academy of Science and Technology
4 Viện Vật Lý, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
Corresponding author: bsdinhtung@gmail.com
DOI: 10.52163/yhc.v64i3.643
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Keywords
PlasmaMed, cold plasma, technology, wound care.
Abstract

Objective: This study aims to assess the safety and effectiveness of using anti-inflammatory and
bactericidal plasma generated from the PlasmaMed machine manufactured in Vietnam for treating
infected wounds.
Methods: This study was a controlled clinical trial involving 31 patients with infected wounds.
Of the 31 patients, 20 had two similar wound areas, with one area treated with plasma irradiation
while the other received routine dressing changes and served as the control group. The remaining 11
patients had only one wound area treated with plasma irradiation. The efficacy of the treatment was
measured using various indicators, including C-reactive protein (CRP), procalcitonin (PCT), and
bacterial concentration at the wound site.
Results: The study showed a significant decrease in CRP and PCT levels immediately after the first
and fifth day of cold plasma irradiation. Additionally, the concentration of bacteria on the wound
surface was significantly reduced after the first plasma irradiation. By day 5, most of the patients’
wounds were completely clean, with positive changes observed, such as fast atrophy, reduced
exudation, healing of wound edges, and tissue growth, resulting in a uniform coloration of the overall
wound surface.
Conclusion: Based on the study results, it can be concluded that cold plasma generated from the
PlasmaMed machine has anti-inflammatory and bactericidal effects that can prevent infection in soft
wounds immediately after the first exposure and up to five days after treatment.

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