Articles Tập 67 Số CĐ13-HNKH Bệnh viện 19-8 10/09/2026

SKIN BARRIER REPAIR CARE IN THE MANAGEMENT OF CHRONIC SKIN DISEASES: A SYSTEMATIC REVIEWDiseases: A Systematic Review

Hiền Nguyễn Thị Thu
DOI: 10.52163/yhc.v67iCD13.6428
0 Views
0 Downloads
Keywords
Skin barrier; chronic skin disease; skin barrier repair; moisturizing; skincare
Abstract

Introduction: Skin barrier dysfunction is considered a core factor in the pathogenesis of many chronic skin diseases. However, interventions to restore the skin barrier have not yet been consistently implemented in clinical practice in Vietnam. Objective: To synthesize existing evidence regarding skin barrier restoration care protocols in the management of chronic skin diseases. Methods: A systematic review was conducted following PRISMA 2020 guidelines and registered on PROSPERO (CRD420251017829). Searches were performed across four databases—PubMed, Ovid, Wiley Online Library, and the Cochrane Library—and data were synthesized using a narrative synthesis approach. Results: A total of 20 studies were included, involving at least 1,343 participants (based on the 17 studies that reported sample sizes). The studies focused primarily on three groups of chronic skin diseases: inflammatory conditions (n ​​= 16), autoimmune diseases (n = 2), and circulatory disorders (n = 2). The findings indicate a shift from the use of simple moisturizers to structured care protocols that incorporate gentle cleansing, bioactive moisturizers, and guidance on treatment adherence. Based on this evidence, the study proposes a three-step care framework comprising: (1) standardized skin cleansing; (2) disease-specific skin barrier restoration; and (3) combined specialized treatment. Conclusion: Existing evidence suggests that skin barrier restoration care is increasingly being implemented through structured protocols, although the specific interventions vary across disease groups. The proposed three-component care framework may serve as a reference for developing and standardizing care protocols for patients with chronic skin diseases in clinical practice.

References
[1]
[1]. Lio PA (2016). Efficacy of a moisturizing foam in skin barrier regeneration and itch relief in subjects prone to atopic dermatitis. J Drugs Dermatol, 15(11), tr. S77–S80. Google Scholar
[2]
[2]. Tsunemi Y, Nakahigashi H (2022). Clinical study on the effects of the applied volume of moisturizer in patients with asteatosis. J Dermatol, 49(1), tr. 75–85. doi:10.1111/1346-8138.16160 Google Scholar
[3]
[3]. Kim S, Ly BK, Ha JH, Carson KA, Hawkins S, Kang S, et al. (2022). A consistent skin care regimen leads to objective and subjective improvements in dry human skin: investigator-blinded randomized clinical trial. J Dermatolog Treat, 33(1), tr. 300–305. doi:10.1080/09546634.2020.1751037 Google Scholar
[4]
[4]. Draelos Z, Hougeir FG, Nguyen TQ, Garimella S, Emesiani C, Qureshi A, et al. (2025). Study of adjuvant sensitive-skin cleansing and moisturizing regimen in plaque psoriasis. J Drugs Dermatol, 24(8), tr. 739–743. doi:10.36849/JDD.9163 Google Scholar
[5]
[5]. Filippi F, Chessa MA, Bardazzi F, Pileri A, Patrizi A (2023). An easy-to-use, ceramide-containing skincare routine: effectiveness and improvement of quality of life in elderly patients with xerosis. Ital J Dermatol Venerol, 158(6), tr. 429–436. doi:10.23736/S2784-8671.23.07533-3 Google Scholar
[6]
[6]. Barbarot S, Aubert H, Vibet MA, Leray M, Foureau A, Elan F, et al. (2024). Effectiveness of a nurse-led one-to-one education programme in addition to standard care in children with atopic dermatitis: a multicentre randomized controlled trial. Br J Dermatol, 191(2), tr. 177–186. doi:10.1093/bjd/ljae111 Google Scholar
[7]
[7]. Elias PM, Wakefield JS (2011). Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis. Clin Rev Allergy Immunol, 41(3), tr. 282–295. doi:10.1007/s12016-010-8231-1 Google Scholar
[8]
[8]. Proksch E, Brandner JM, Jensen JM (2008). The skin: an indispensable barrier. Exp Dermatol, 17(12), tr. 1063–1072. doi:10.1111/j.1600-0625.2008.00786.x Google Scholar
[9]
[9]. Wollenberg A, Kinberger M, Arents B, et al (2025). European Guideline (EuroGuiDerm) on atopic eczema: Living update. J Eur Acad Dermatol Venereol, 39(9), tr. 1537-1566. doi:10.1111/jdv.20639 Google Scholar
[10]
[10]. Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, et al. (2009). Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol, 129(8), tr. 1892–1908. doi:10.1038/jid.2009.133 Google Scholar