Background: Synchronous multiple primary neoplasms (MPN) of the gastrointestinal tract are rare clinical entities and easily overlooked in diagnosis. Accurate staging of each tumor to devise an individualized treatment strategy is the key factor in improving survival prognosis. Methods: This report presents two clinical cases of synchronous gastric and colorectal cancer treated at 19-8 Hospital in 2025: Case 1: A 77-year-old male with advanced gastric cancer (T4a) and early-stage right colon cancer (T1). Treatment involved a combination of endoscopic mucosal resection (EMR) for the colonic lesion and subtotal gastrectomy with D2 lymph node dissection. Case 2: A 48-year-old male with both advanced gastric cancer (T3/T4a) and advanced sigmoid colon cancer (T3/T4a). The patient underwent simultaneous double radical surgery: subtotal gastrectomy (D2) and radical sigmoidectomy. Conclusion: Synchronous gastrointestinal cancers require high clinical suspicion. Comprehensive gastrointestinal endoscopy and contrast-enhanced abdominal CT scans are mandatory to avoid missing secondary lesions. Simultaneous radical surgery or a combination of endoscopic intervention and surgery provides an effective and safe treatment solution when tailored to the patient’s performance status and disease stage.
INDIVIDUALIZED TREATMENT STRATEGIES FOR SYNCHRONOUS MULTIPLE PRIMARY GASTROINTESTINAL NEOPLASMS: CASE REPORTS AND LITERATURE REVIEW
0
Views
0
Downloads
Keywords
Multiple primary neoplasms, gastric cancer, colorectal cancer, synchronous cancer, radical surgery, individualized treatment.
Abstract
References
[1]
1. Billroth T. Die allgemeine chirurgische Pathologie und Therapie in 51 Vorlesungen. Reimer, Berlin, 1889.
Google Scholar
[2]
2. Gül Bora, Bilgehan Çağdaş (2016). “Synchronous gastric and colon carcinomas: A case report and review of literature”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 69(2), pp. 129-131.
Google Scholar
[3]
3. Nedim Akgül, Volkan Doğru (2016). “A Rare Case: Synchronous Gastric and Colon Cancer”. Turk J Colorectal Dis, 26, pp. 130-132.
Google Scholar
[4]
4. Bratislav Trifunović, Branimir Nešković (2015). “Synchronous gastric and colonic cancer – A case report”. Vojnosanit Pregl, 72(7), pp. 642-645.
Google Scholar
[5]
5. Puneet Kumar Bagri, Daleep Singh (2014). “Double primary malignancies: A clinical & pathological analysis report from a regional cancer institute in India”. Iranian Journal of Cancer Prevention, 7(2), pp. 66-72.
Google Scholar
[6]
6. Warren S, Gates O (1932). “Multiple primary malignant tumors. A survey of the literature and a statistical study”. Am J Cancer, 16, pp. 1358-1414.
Google Scholar
[7]
7. Jun Ho Lee, Ja Seong Bae (2006). “Gastric cancer patients at high-risk of having synchronous cancer”. World J Gastroenterol, 12(16), pp. 2588-2592.
Google Scholar
[8]
8. Małgorzata Ławniczak (2014). “Synchronous and metachronous neoplasms in gastric cancer patients: A 23-year study”. World J Gastroenterol, 20(23), pp. 7480-7487.
Google Scholar
[9]
9. Aoyama T, Ju M, Komori K, et al. (2022). “The Clinical Impact of Synchronous and Metachronous Other Primary Cancer in Gastric Cancer Patients Who Receive Curative Treatment”. In Vivo, 36(5), pp. 2514-2520.
Google Scholar
[10]
10. Campuzano N, Trokhimtchouk TF, Flores LF, et al. (2023). “Synchronous gastric and colon cancer”. Cureus, 15(11), e48912.
Google Scholar