Articles Vol. 64 No. 3 24/04/2023

1. PREVALENCE OF POTENTIALLY INAPPROPRIATE MEDICATION USE AMONG HOSPITALIZED ELDERLY PATIENTS AND ASSOCIATED FACTORS

Nguyen Van Tan1,2, Bang Ai Vien1,2, Dang Tran Truc Phuong1,2
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 Đại Học Y Dược Thành phố Hồ Chí Minh
Corresponding author: nguyenvtan10@ump.edu.vn
DOI: 10.52163/yhc.v64i3.633
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Keywords
Potentially inappropriate medication, 2019 beers criteria, elderly patients.
Abstract

Background: Multimorbidity and polypharmacy are common problems among the older population.
They increase the risk of potentially inappropriate medication (PIMs) use and are related to adverse
events, falls, re-hospitalization and mortality.
Objectives: The study aimed to determine the prevalence and associated factors of PIMs in
hospitalized geriatric patients based on the 2019 Beers criteria.
Methods: A cross-sectional descriptive study was collected from the medical records of patients 65
years of age or older who were treated at the Cardiovascular Center, Thong Nhat Hospital, HCM
City, from December 2020 to June 2021. The PIMs were classified according to the 2019 Beers
criteria (AGS) version. We also collected the medication information (quantity, dosage, regime),
chronic diseases, Charlson comorbidities index, frailty, history of falls, and re-hospitalization in the
last year.
Results: A total of 215 eligible patients with 619 prescriptions were included. The mean age was 76.2
± 7.9 years. The frailty rate (CFS ≥ 5) was 54.9%. The ACCI scores were from 2 to 9. There were
88.4% of the patients took 5 or more medications simultaneously. The prevalence of PIMs use based
on the 2019 Beers criteria was 31.2%. The criteria on drugs to avoid, on drug–disease interactions
and drug–drug interactions were 87.6%, 10.4%, and 2%, respectively. The common PIMs were
long-acting benzodiazepines (27.2%). Logistic regression demonstrated that frailty, polypharmacy,
multiple comorbidities, and history of falls were positively associated with PIM use in older adults,
p < 0.05.
Conclusions: The prevalence of PIMs use was 31.2%. Factors that increase the risk of PIMs were
frailty, polypharmacy, history of falls, and rehospitalization.

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