Articles Vol. 67 No. 8 28/08/2026

ANTIBIOTIC RESISTANCE PROFILE OF Escherichia coli STRAINS ISOLATED FROM CLINICAL SPECIMENS AT DUC GIANG GENERAL HOSPITAL DURING THE FIRST FIVE MONTHS OF 2026

Do Dinh Tung1,2, Dao Quang Trung1,2, Nguyen Hoai Giang3,4
1 Duc Giang General Hospital
2 Bệnh viện Đa khoa Đức Giang
3 International Medical Training Institute, Dai Nam University
4 Viện Đào tạo Y khoa Quốc tế, Trường Đại học Đại Nam
DOI: 10.52163/yhc.v67i8.6307
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Keywords
Escherichia coli; antibiotic resistance; multi-drug resistant (MDR); ESBL; Carbapenem.
Abstract

Objective: To evaluate the antibiotic resistance status and distribution characteristics of clinical E. coli strains at Duc Giang general hospital during the first five months of 2026.

Materials and Methods: A cross-sectional, retrospective study analyzing data from 126 non-duplicate E. coli strains isolated from January to May 2026. Antimicrobial susceptibility testing (AST) was performed using an automated VITEK® 2 Compact system (BioMérieux, France) in accordance with CLSI standards.

Results: Female patients accounted for 54.8%, and individuals aged ≥60 years constituted 62.7%. The bacterial strains were primarily distributed across the Surgical Division (44.4%) and Medical Division (25.4%), with the highest isolation rates obtained from urine (33.3%) and blood (26.2%). E. coli showed high resistance to Ampicillin (93.7%), Ciprofloxacin (72.2%), Sulfamethoxazole/Trimethoprim (72.2%), and Cefotaxime (62.7%). The multidrug resistance (MDR) rate reached 84.1%, while suspected ESBL-producing phenotypes accounted for 64.3%, and Carbapenem-resistant E. coli (CRE) accounted for 11.9%. Amikacin (96.6% susceptible) and Amikacin, tested on 116 isolates, demonstrated a susceptibility rate of 96.6% (112/116) with 0.0% resistance and 3.4% (4/116) intermediate susceptibility. In accordance with clinical microbiology standards, Nitrofurantoin was evaluated exclusively for urine isolates (), achieving a 100% (42/42) susceptibility rate, although its clinical applicability is strictly restricted to uncomplicated lower urinary tract infections. The Carbapenem class sustained a susceptibility rate above 88%.

Conclusion: The high rates of multidrug resistance and suspected ESBL phenotypes in E. coli are concerning, accompanied by the emergence of CRE strains. Antibiotic stewardship programs and infection control measures must be reinforced to prevent the dissemination of these highly drug-resistant strains.

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