Articles Vol. 67 No. 8 28/08/2026

CORRELATION BETWEEN PLASMA FERRITIN LEVELS AND BIOCHEMICAL AND HEMATOLOGICAL INDICES IN PATIENTS WITH PROLONGED FEVER STRATIFIED BY ETIOLOGY

Nguyen Hoai Nam1,2, Dao Huyen Quyen1,2, Tran Thi Quynh Anh3,4
1 Bach Mai Hospital
2 Bệnh viện Bạch Mai
3 National Lung Hospital
4 Bệnh viện Phổi Trung Ương
DOI: 10.52163/yhc.v67i8.6304
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Keywords
Plasma ferritin, prolonged fever, infectious, non-infectious, GOT, LDH, platelets, RBC.
Abstract

Objective: To investigate the correlation between plasma ferritin levels and biochemical/hematological indices in prolonged fever patients stratified by infectious and non-infectious etiologies at Bach Mai Hospital. Methods: A cross-sectional descriptive study on 60 inpatients with prolonged fever (Jun 2022 – Jun 2023). Pearson correlation coefficients were analyzed using SPSS 20.0. Results: In the infectious group, ferritin correlated positively with PCT (r=0,51; p=0,001), GOT (r=0,58; p<0,01), GPT (r=0,38; p=0,021) and LDH (r=0,41; p=0,012). In the non-infectious group, ferritin correlated positively with PCT (r=0,65, p = 0,001), GOT (r=0,61, p = 0,001), GPT (r=0,43, p = 0,034), LDH (r=0,53, p = 0,008) and negatively with PLT (r=-0.59; p=0.002) and RBC (r=-0.42; p=0.04). Average value of LDH was significantly higher in the non-infectious group was 460 U/l and in the infectious group was 291 U/L (p=0.023). Conclusion: Plasma ferritin levels are possitively correlated with hepatocellular damage (GOT, GPT), tissue injury (LDH), and inflammation (PCT). In the non-infectious group, ferritin additionally inversely correlated with RBC and PLT, reflecting multi-organ involvement.

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