Articles Vol. 64 No. 2 15/03/2023

27. VALUE OF CFFDNA CONCENTRATIONS IN NIPT FOR PRENATAL SCREENING OF DOWN SYNDROME

Vu Thi Thuy Chi1,2, Trinh Thi Que1,2, Nguyen Ba Son1,2, Nguyen Dang Thu Phuong1,2, Hoang Thi Ngoc Lan3,4, Luong Thi Lan Anh3,4
1 MEDLATEC general Hospital
2 Bệnh viện Đa khoa Medlatec
3 Hanoi Medical University
4 Trường Đại học Y Hà Nội
Corresponding author: drvuthithuychi@gmail.com
DOI: 10.52163/yhc.v64i2.630
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Keywords
NIPT, cffDNA, trisomy 21.
Abstract

Research objectives: Analyzing the value of cffDNA levels in non-invasive prenatal testing (NIPT)
for Down syndrome.
Research method and duration: A retrospective cross-sectional descriptive study on 17,451
pregnant women who received NIPT from October 2020 to July 2022.
Results and conclusions: There was a positive correlation between the cffDNA concentration and the
gestational week, but negatively correlated with the age of the pregnant woman in the study. Among
the group of pregnant women with positive NIPT results, there was a strong positive correlation
between the cffDNA concentration and z-score.

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