Articles Vol. 67 No. Số CĐ12- Bệnh viện Ung bướu Nghệ An (2026) 25/08/2026

ANATOMICAL VARIATIONS CAUSING LEFT RENAL VEIN COMPRESSION IN NUTCRACKER SYNDROME: A CASE REPORT

Ngo Xuan Khoa1,2,3,4, Ngo Xuan Khoa1,2,3,4, Ngo Thanh Y5,6, Nguyen Thi Thuy1,3, Le Van Dung1,3
1 Hanoi Medical University Hospital
2 Hanoi Medical University
3 Bệnh viện Đại học Y Hà Nội
4 Trường Đại học Y Hà Nội
5 115 People’s Hospital
6 Bệnh viện Nhân Dân 115
DOI: 10.52163/yhc.v67iCD12.6290
255 Views
0 Downloads
Abstract

Background: Nutcracker syndrome refers to compression of the left renal vein between the superior mesenteric artery and the abdominal aorta. Although uncommon, it is an important diagnosis because of its associated complications, including the risk of chronic kidney disease secondary to prolonged renal venous hypertension and the potential development of renal vein thrombosis.

Case presentation: A 52 year old female with no significant past medical history presented with dull left flank pain and lower abdominal pain associated with severe dysmenorrhea. Computed tomography demonstrated compression of the left renal vein between the abdominal aorta and the superior mesenteric artery, along with dilatation of the ovarian vein. With a diagnosis of Nutcracker syndrome, the patient underwent ovarian vein embolization. Following the intervention, the patient experienced significant symptom relief and was discharged after 2 days. Follow-up examinations at 1 month and 3 months showed favorable outcomes.

Conclusion: Ovarian vein embolization may represent a minimally invasive and effective therapeutic option for patients with Nutcracker syndrome presenting predominantly with pelvic congestion syndrome. However, treatment strategies should be individualized for each specific case.

References
[1]
de Macedo G.L, Dos Santos M.A, Sarris A.B, Gomes R.Z. Diagnosis and treatment of the Nutcracker syndrome: a review of the last 10 years. J Vasc Bras, 2018, 17 (3): 220-8. doi: 10.1590/1677-5449.012417. Google Scholar
[2]
Ananthan K, Onida S, Davies A.H. Nutcracker syndrome: an update on current diagnostic criteria and management guidelines. Eur J Vasc Endovasc Surg Off J Eur Soc Vasc Surg, 2017, 53 (6): 886-94. doi: 10.1016/j.ejvs.2017.02.015. Google Scholar
[3]
Penfold D, Leslie S.W, Lotfollahzadeh S. Nutcracker syndrome and left renal vein entrapment. In: StatPearls. StatPearls Publishing, 2024 [cited 2026 May 24]. https://www.ncbi.nlm.nih.gov/books/NBK559189/ PubMed PMID: 32644615. Google Scholar
[4]
Orczyk K, Wysiadecki G, Majos A, Stefańczyk L, Topol M, Polguj M. What each clinical anatomist has to know about left renal vein entrapment syndrome (Nutcracker syndrome): a review of the most important findings. BioMed Res Int, 2017, 2017: 1746570. doi: 10.1155/2017/1746570. Google Scholar
[5]
Kalantar D.S, Park S.J, Shin J.I. Nutcracker syndrome in children: review of symptom, diagnosis, and treatment. Child Kidney Dis, 2023, 27 (2): 89-96. doi: 10.3339/ckd.23.018 Google Scholar
[6]
Mačionienė E, Kerpauskienė A, Žakauskienė U, Vitkauskaitė M, Girčius R, Miglinas M. Nutcracker syndrome in 2026: a nephrologist-oriented diagnosis and management. Clin Kidney J, 2026, 19 (5): sfag124. doi: 10.1093/ckj/sfag124 Google Scholar
[7]
Mosavari H, Sarafi M, Hosseininasab A, Narimani N, Khaleghian M, Saberi A. Renal nutcracker syndrome presenting with varicocele: a case series. Int J Surg Case Rep, 2024, 124 (C): 110393. doi: 10.1016/j.ijscr.2024.110393 Google Scholar
[8]
Ribeiro F.S, Puech-Leão P, Zerati A.E, Nahas W.C, David-Neto E, De Luccia N. Prevalence of left renal vein compression (nutcracker phenomenon) signs on computed tomography angiography of healthy individuals. J Vasc Surg Venous Lymphat Disord, 2020, 8 (6): 1058-65. doi: 10.1016/j.jvsv.2020.04.005. Google Scholar
[9]
Perkov D, Vrkić Kirhmajer M, Novosel L, Popić Ramač J. Transcatheter ovarian vein embolisation without renal vein stenting for pelvic venous congestion and nutcracker anatomy. VASA Z Gefasskrankheiten, 2016, 45 (4): 337-41. doi: 10.1024/0301-1526/a000547. Google Scholar
[10]
Maleux G, Stockx L, Wilms G, Marchal G. Ovarian vein embolization for the treatment of pelvic congestion syndrome: long-term technical and clinical results. J Vasc Interv Radiol JVIR, 2000, 11 (7): 859-64. doi: 10.1016/s1051-0443(07)61801-6. Google Scholar
[11]
d’Archambeau O, Maes M, De Schepper A.M. The pelvic congestion syndrome: role of the “Nutcracker phenomenon” and results of endovascular treatment. JBR-BTR Organe Soc R Belge Radiol SRBR Orgaan Van K Belg Ver Voor Radiol, 2004, 87 (1): 1-8. Google Scholar