Articles Vol. 67 No. Số CĐ12- Bệnh viện Ung bướu Nghệ An (2026) 25/08/2026

CLINICAL AND HISTOPATHOLOGICAL CHARACTERISTICS AND SELECTED TREATMENT OUTCOMES OF MALIGNANT OCULAR SURFACE TUMORS IN 206 PATIENTS AT VIETNAM NATIONAL EYE HOSPITAL

Nguyen Thi Phuong Thao1,2, Tran Khanh Sam3,4, Tran Thi Thanh Huong1,2, Do Tuyet Nhung3,4, Tran Thi Huong Tra3,4
1 Hanoi Medical University.
2 Trường Đại học Y Hà Nội.
3 Vietnam National Institute of Ophthalmology.
4 Bệnh viện Mắt Trung ương.
DOI: 10.52163/yhc.v67iCD12.6278
288 Views
0 Downloads
Keywords
malignant ocular surface tumor; squamous cell carcinoma; conjunctival melanoma; conjunctival lymphoma; orbital exenteration.
Abstract

Objective: To describe the clinical and histopathological characteristics and selected treatment outcomes of three groups of malignant ocular surface tumors at Vietnam National Eye Hospital.

Methods: This retrospective descriptive study with longitudinal follow-up included 206 patients with histopathologically confirmed squamous cell carcinoma, malignant melanoma, or conjunctival lymphoma who were treated at Vietnam National Eye Hospital between 2014 and 2023.

Results: Squamous cell carcinoma was diagnosed in 129 patients (62.6%); corneal invasion occurred in 52.7%, orbital exenteration was performed in 8.5%, and suspected tumor-related death was recorded in 1.6%. Malignant melanoma was predominantly of the epithelioid cell type (57.9%), with a median follow-up of 44 months, an orbital exenteration rate of 31.6%, and a tumor-related or suspected tumor-related mortality rate of 44.7%. Most conjunctival lymphomas were low-grade tumors (74.4%); the median follow-up was 46 months, and mortality related to malignant lymphohematologic disease was 10.3%.

Conclusion: Squamous cell carcinoma was the most common tumor group. Malignant melanoma was associated with high rates of orbital exenteration and tumor-related or suspected tumor-related mortality, whereas conjunctival lymphoma should be evaluated in the context of systemic lymphohematologic disease.

References
[1]
McKelvie PA, Daniell M, McNab A, Loughnan MS, Santamaria JD. Squamous cell carcinoma of the conjunctiva: a series of 26 cases. Br J Ophthalmol. 2002;86(2):168-173. doi:10.1136/bjo.86.2.168. Google Scholar
[2]
Shields CL, Kaliki S, Al-Dahmash S, Lally SE, Shields JA. Conjunctival melanoma: outcomes based on tumor origin in 382 consecutive cases. Ophthalmology. 2011;118(2):389-395.e1-e2. Google Scholar
[3]
Shields CL, Shields JA, Carvalho C, Rundle P, Smith AF. Conjunctival lymphoid tumors: clinical analysis of 117 cases and relationship to systemic lymphoma. Ophthalmology. 2001;108(5):979-984. Google Scholar
[4]
Goto H, Asakage M, Niidime E, Yamakawa N, Komatsu H, Tsubota K, et al. Demographics, clinical features and prognosis of patients with primary malignant conjunctival tumors at a tertiary hospital in Japan. Jpn J Ophthalmol. 2025;69:316-325. doi:10.1007/s10384-025-01165-8. Google Scholar
[5]
Nguyễn Thu Thủy. Nghiên cứu chẩn đoán và điều trị u biểu mô bề mặt nhãn cầu. Luận án tiến sĩ y học. Trường Đại học Y Hà Nội; 2012. Google Scholar
[6]
Rajeh A, Barakat F, Khurma S, AlRawashdeh K, Ababneh OH, AlNawaiseh I, et al. Characteristics, management, and outcome of squamous carcinoma of the conjunctiva in a single tertiary cancer center in Jordan. Int J Ophthalmol. 2018;11(7):1132-1138. doi:10.18240/ijo.2018.07.10. Google Scholar
[7]
Tananuvat N, Niparugs M, Wiwatwongwana D, Lertprasertsuk N, Mahanupab P. Ocular surface squamous neoplasia in Northern Thailand: a 16-year review. BMC Ophthalmol. 2022;22:121. doi:10.1186/s12886-022-02340-y. Google Scholar
[8]
Jain P, Finger PT, Fili M, et al. Conjunctival melanoma treatment outcomes in 288 patients: a multicentre international data-sharing study. Br J Ophthalmol. 2021;105(10):1358-1364. doi:10.1136/bjophthalmol-2020-316293. Google Scholar
[9]
Kaliki S, Vasanthapuram VH, Mishra DK, et al. Conjunctival melanoma in Asian Indians: a study of 42 patients. Semin Ophthalmol. 2019;34(6):376-384. doi:10.1080/08820538.2019.1620793. Google Scholar
[10]
Kirkegaard MM, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, et al. Conjunctival lymphoma: an international multicenter retrospective study. JAMA Ophthalmol. 2016;134(4):406-414. doi:10.1001/jamaophthalmol.2015.6122. Google Scholar