Articles Vol. 67 No. Số CĐ12- Bệnh viện Ung bướu Nghệ An (2026) 14/08/2026

THE ASSOCIATION BETWEEN NEUTROPHIL-TO-LYMPHOCYTE RATIO AND SOME CLINICAL CHARACTERISTICS OF CHRONIC HEPATITIS B VIRUS INFECTION-RELATED HEPATOCELLULAR CARCINOMA

Nguyen Thi Mai Ly1,2, Pham Thi Phuong Thao1,2, Ngo Hoang Anh3,4, Bui Khac Cuong5,6
1 Department of Biochemistry, 103 Military Hospital, Vietnam Military Medical University
2 Bộ môn - Khoa Sinh hóa, Bệnh viện Quân y 103, Học viện Quân y
3 Military Medical Section, Logistics and Technical Division, Military Technical Academy
4 Ban Quân y, Phòng Hậu cần - Kỹ thuật, Học viện Kỹ thuật Quân sự
5 Department of Experimental Medicine, 108 Military Central Hospital
6 Khoa Y học thực nghiệm, Bệnh viện Trung ương Quân đội 108
DOI: 10.52163/yhc.v67iCD12.6170
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Keywords
Hepatocellular carcinoma, hepatitis B virus, HBV-HCC.
Abstract

Objective: To evaluate the association between the neutrophil-to-lymphocyte ratio (NLR) and the clinical characteristics of patients with chronic hepatitis B virus-related hepatocellular carcinoma (HBV-HCC).

Methods: A cross-sectional descriptive study was conducted on 100 patients diagnosed with HBV-HCC.

Results: The NLR was significantly higher in patients with Child-Pugh class B and C compared to those with Child-Pugh class A (p = 0.004). HBV-HCC patients with a larger maximum tumor size exhibited a higher NLR (p = 0.0013). Furthermore, hepatocellular carcinoma patients with portal vein thrombosis had a significantly higher NLR than those without thrombosis (p = 0.023). Additionally, the NLR was elevated in subgroups presenting with weight loss (p = 0.0029), mucocutaneous jaundice (p = 0.0445), and collateral circulation (p = 0.0216). Conversely, there were no significant differences in the NLR among subgroups stratified by tumor number, metastasis status, or cancer stage.

Conclusion: A higher NLR is observed in HBV-HCC patients presenting with Child-Pugh class B and C, larger tumor sizes, portal vein thrombosis, weight loss, mucocutaneous jaundice, and collateral circulation. The NLR is not associated with cancer stages, metastasis, or the number of tumors.

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