Articles Vol. 67 No. CĐ11-NCKH 31/07/2026

A COMPARISON OF SALIVARY CORTISOL LEVELS IN PATIENTS WITH AND WITHOUT PERIODONTAL DISEASE

Huynh Ngoc Thao Uyen1,2, Le Do Tuan Kiet1,2, Do Thu Hang3,4
1 Nguyen Tat Thanh University
2 Trường Đại học Nguyễn Tất Thành
3 University of Medicine and Pharmacy at Ho Chi Minh city
4 Đại học Y Dược thành phố Hồ Chí Minh
DOI: 10.52163/yhc.v67iCD11.6049
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Keywords
Salivary cortisol levels, periodontal disease, psychological stress, salivary biomarkers.
Abstract

Objective: To investigate the association between salivary cortisol levels and periodontal disease.

Methods: A cross-sectional study was conducted on 174 patients who visited the Ho Chi Minh city Hospital of Odonto-Stomatology for examination and treatment. They were divided into 3 groups: H (healthy periodontal tissue), G (gingivitis), P (periodontitis).  Periodontal tissue was examined and PPD, CAL, BOP, and PI indices were recorded; unstimulated saliva samples were taken. The significance threshold p < 0.05 was applied to all statistical tests.

Results: Salivary cortisol levels were significantly greater in the 2 periodontal disease  groups compared to the healthy group, with group G showing the highest level (p < 0.05). No association was found between salivary cortisol and BOP, PI, and severity of periodontal disease  (p > 0.05).

Conclusion: An initial association was discovered between salivary cortisol levels and the presence or absence of periodontal disease. Further research is needed to better define the association between cortisol and periodontal disease.

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