Articles Vol. 64 No. 2 15/03/2023

2. CLINICAL AND SUBCLINICAL CHARACTERISTICS OF MULTIPLE MYELOMA PATIENTS

Phan Nguyen Thanh Van1,2, Cao Thi Loc3,4, Tong Duc Minh5,6
1 Pham Ngoc Thach University of Medicine
2 Trường Đại học Y khoa Phạm Ngọc Thạch
3 Blood Transfusion Hematology Hospital
4 Bệnh viện Truyền máu Huyết học
5 Vietnam Military Medical University
6 Học viện Quân y
Corresponding author: pnthanhvan@pnt.edu.vn
DOI: 10.52163/yhc.v64i2.604
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Keywords
Multiple myeloma, clinical and subclinical characteristics.
Abstract

Objectives: To describe the clinical and subclinical characteristics of patients with multiple
myeloma. Subjects and methods: A retrospective and prospective descriptive study on 96 patients
with multiple myeloma diagnosed, treated and autologous stem cell transplantation at the Ho Chi
Minh City Blood Transfusion Hematology Hospital from 2018 to 2021. Results: The most common
form of multiple myeloma was monoclonal IgG (62.8%), followed by IgA monoclonal increase
(18.75%) and light chain (18.75%). The group of multiple myeloma patients in stage II accounted
for the highest percentage (69.8%), followed by stage I (18.7%). The number of patients hospitalized
in stage III accounted for the lowest rate (11.5%). The mean hemoglobin concentration was 94.1 ±
20.4 (g/l), white blood cell count (6.42 ± 2.38 G/l), platelet count (186.4 ± 75.3 G/l) l), bone marrow
cell count (71.16 ± 68.7 G/l), percentage of plasma cell lineage in the marrow (35.6 ± 21.3 %). IgG
(6281.0 ± 2938.6 mg/L), IgA (3521.4 ± 1405.3 mg/L), Free Kappa (1201.5 ± 1422.1), Free Lambda
(2194.7 ± 2421) ,1), ß2 microglobulin (4.24 ± 6.67 mg/L). Conclusion: The most common type of
multiple myeloma was monoclonal IgG. The group of patients with multiple myeloma in stage II
accounted for the highest percentage.

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