Articles Vol. 62 No. 3 (2021) 05/05/2021

ACUTE TOXICITY STUDY OF SUBMERGED-FERMENTATION OF PHELLINUS LINTEUS BIOMASS POWDER

Bạch Thị Như Quỳnh1, Nguyễn Thị Liên2, Phạm Đức Cường3, Ninh Thị Tuyết Lan3, Nguyễn Thị Minh Huyền4
1 Trường Đại học Y Dược Hải Phòng
2 Viện Kiểm nghiệm thuốc Trung ương
3 Viện Công nghệ HaUI
4 Viện Công nghệ sinh học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
Corresponding author: ntminhhuyen@ibt.ac.vn
DOI: 10.52163/yhc.v62i3 (2021).58
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Keywords
Phellinus linteus, acute toxicity, submerged fermentation, mouse, biomass.
Abstract

Objective: Evaluation of acute toxicity of Phellinus linteus biomass powder which obtained from submerged-fermentation in Institute of Biotechnology, VAST. Methods: Method for evaluation of drug toxicity, Medicinal Publishing House and OECD guidelines for testing of chemicals. Results and conclusions: The dose that did not cause abnormal symptoms observed in the trial was 18.0 g of sample / kg of mice. Lethal dose of 50% of experimental animals (LD50) was greater than 18.0 g of test sample / kg of mice. The results showed that mushroom biomass had low toxicity below the GHS classification threshold and did not cause toxicity to test animals.

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