Articles Vol. 67 No. CĐ8-NCKH 06/07/2026

PROGNOSTIC VALUE OF THE FRAILTY SCALE FOR MORTALITY IN ELDERLY PATIENTS ADMITTED TO THE TOXICOLOGY INTENSIVE CARE UNIT.

Hoang Van Quang1,2,3,4, Pham Thi Thanh Thuy2,4, Tran Thi Thu Hien2,4, Vu Trung Hieu2,4
1 Faculty of Medicine, Nguyen Tat Thanh University
2 Department of Intensive Care and Toxicology, Thong Nhat Hospital
3 Khoa Y, Đại học Nguyễn Tất Thành
4 Khoa Hồi sức tích cực chống độc Bệnh viện Thống Nhất
DOI: 10.52163/yhc.v67iCD8.5668
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Keywords
Clinical Frailty Scale, Toxicology Intensive Care Unit, Mortality Rate
Abstract

Objective: To evaluate the prognostic value of the Clinical Frailty Scale (CFS) for mortality in elderly patients admitted to the Toxicology Intensive Care Unit (ICU).

Subjects and Methods: This was a prospective observational cohort study with longitudinal follow-up on 95 patients aged ≥60 years who were hospitalized in the ICU of Thong Nhat Hospital from January 1, 2025 to June 30, 2025. Frailty was assessed 2 weeks prior to hospitalization through interviews with family members. A patient was considered frail when the CFS score was ≥5. Treatment outcomes were divided into two groups: survival and death.

Results: The mean age was 76.7 years, and males accounted for 51.6%. The prevalence of frailty was 84.2%. A Charlson Comorbidity Index (CCI) >7 was found in 15.8% of patients. The most common comorbidities were hypertension (82.1%) and diabetes mellitus (42.1%). The ICU mortality rate was 57.9%. Two factors were significantly associated with in-hospital mortality: frailty (OR 2.33; 95% CI 1.95–8.79; p<0.015) and polypharmacy (OR 5.57; 95% CI 1.69–8.35; p<0.001). The Clinical Frailty Scale demonstrated prognostic value for mortality with an area under the curve (AUC) of 0.83, a cut-off point of 4.5, sensitivity of 98.2%, and specificity of 62.5%.

Conclusion: Frailty is common among the elderly. The frailty scale was significantly associated with in-hospital mortality and demonstrated fair discriminatory performance in predicting mortality among elderly patients admitted to the Toxicology Intensive Care Unit.

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