Articles Vol. 67 No. CĐ7-Trường ĐH Y Dược Hải Phòng 06/07/2026

CHARACTERISTICS AND PREGNANCY OUTCOMES IN WOMEN WITH PREECLAMPSIA: A COMPARISON BETWEEN SPONTANEOUS CONCEPTION AND IN VITRO FERTILIZATION

Vu Van Du1,2, Nguyen Phuong Tu3,4, Nguyen Thi Hang1,2, Do Dang Cuong3,4, Trinh Trong Quyen3,4, Dang Van Tot3,4
1 National Hospital of Obstetrics and Gynecology
2 Bệnh viện Phụ sản Trung ương
3 Hanoi Medical University
4 Trường Đại học Y Hà Nội
DOI: 10.52163/yhc.v67iCD7.5645
30 Views
17 Downloads
Keywords
preeclampsia, in vitro fertilization, pregnancy outcomes, retrospective cohort.
Abstract

Objectives: To compare clinical characteristics, disease severity and pregnancy outcomes between spontaneously conceived and in vitro fertilization (IVF) pregnancies among women already diagnosed with preeclampsia.

Methods: A retrospective cohort study based on medical-record review was conducted on 607 women with preeclampsia at Hanoi Obstetrics and Gynecology Hospital, 2021–2025 (500 spontaneous, 107 IVF). Clinical, laboratory, and pregnancy outcome data were collected and compared between the two groups. Multivariable logistic and linear regression adjusted for maternal age, parity and multiple pregnancy. Given the substantial difference in the rate of multiple pregnancy between the two groups and the dual role of multiple pregnancy as both a potential confounder and a mediator in the analysis of IVF effects, we additionally performed a repeated analysis restricted to singleton pregnancies.

Results: Maternal age, nulliparity and multiple pregnancy were higher in the IVF group (p < 0.05). Rates of severe and early-onset preeclampsia were similar. Platelet count was lower in IVF (p < 0.05) but the proportion with platelets < 100 G/L did not differ (1.9% vs 2.8%, p = 0.75). Pregnancy outcomes were similar between groups. After adjustment, IVF was not independently associated with any outcome.

Conclusions: Among women already diagnosed with preeclampsia at the study site, IVF conception was not independently associated with disease severity or pregnancy outcomes after adjustment for maternal age, parity and multiple pregnancy. Further studies stratified by IVF technique are needed for confirmation.

References
[1]
American College of Obstetricians and Gynecologists. Gestational hypertension and preeclampsia. Practice Bulletin No. 222. Obstet Gynecol. 2020;135(6):e237-e260. doi:10.1097/AOG.0000000000003891. Google Scholar
[2]
World Health Organization. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia. Geneva: WHO; 2011. Google Scholar
[3]
Omani-Samani R, Alizadeh A, Almasi-Hashiani A, Mohammadi M, Maroufizadeh S, Navid B, et al. Risk of preeclampsia following assisted reproductive technology: systematic review and meta-analysis of 72 cohort studies. J Matern Fetal Neonatal Med. 2020;33(16):2826-2840. doi:10.1080/14767058.2018.1560406. Google Scholar
[4]
Qin JB, Liu X, Sheng X, Wang H, Gao S. Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies: a meta-analysis of cohort studies. Fertil Steril. 2016;105(1):73-85.e6. doi:10.1016/j.fertnstert.2015.09.007. Google Scholar
[5]
Wang YA, Chughtai AA, Farquhar CM, et al. Increased incidence of gestational hypertension and preeclampsia after assisted reproductive technology treatment. Fertil Steril. 2016;105(4):920-926.e2. doi:10.1016/j.fertnstert.2015.12.024. Google Scholar
[6]
Tranquilli AL, Brown MA, Zeeman GG, Dekker G, Sibai BM. The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Pregnancy Hypertens. 2013;3(1):44-47. doi: 10.1016/j.preghy.2012.11.001. Google Scholar
[7]
Hồ Sỹ Hùng, Mai Hồng Chuyên, Trịnh Thế Sơn. So sánh đặc điểm lâm sàng và kết cục thai kỳ ở sản phụ tiền sản giật giữa thai tự nhiên và thai thụ tinh trong ống nghiệm. Tạp chí Nghiên cứu Y học. 2025;186(1):177-183. doi:10.52852/tcncyh.v186i1.2963. Google Scholar
[8]
Chih HJ, Elias FTS, Gaudet L, Velez MP. Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses. BMC Pregnancy Childbirth. 2021;21:449. doi:10.1186/s12884-021-03938-8. Google Scholar
[9]
Kornfield MS, Gurley SB, Vrooman LA. Increased risk of preeclampsia with assisted reproductive technologies. Curr Hypertens Rep. 2023;25:251-261. doi:10.1007/s11906-023-01277-7. Google Scholar