Articles Vol. 67 No. CĐ7-Trường ĐH Y Dược Hải Phòng 06/07/2026

PREDICTIVE VALUE OF D-DIMER FOR THROMBOSIS, DISEASE STAGE, AND METASTASIS IN CANCER PATIENTS ACROSS ORGAN SYSTEMS

Nguyen Duy Hung1,2, Tran Quang Hung3,4, Pham Thi Loc1,2
1 Hai Phong University of Medicine and Pharmacy, Vietnam
2 Trường Đại học Y Dược Hải Phòng, Việt Nam
3 Viet Tiep Friendship Hospital, Hai Phong, Vietnam
4 Bệnh viện Hữu Nghị Việt Tiệp Hải Phòng, Việt Nam
DOI: 10.52163/yhc.v67iCD7.5596
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Keywords
D-dimer, huyết khối, giai đoạn bệnh, di căn, ung thư.
Abstract

Objective: To evaluate the value of D-dimer in predicting thrombosis, disease stage and metastasis across cancer organ systems.

Subjects and methods: A descriptive, cross-sectional analytical study on 557 cancer patients who underwent D-dimer testing from January 2024 to January 2026. Diagnostic value was assessed using ROC curves and area under the curve (AUC).

Results: The majority of patients were diagnosed at a late stage, particularly esophageal (97.14%), gastric (93.1%) and lung cancer (91.26%). Metastasis rates were highest in respiratory (70.48%), digestive (61.8%) and reproductive cancers (60.27%). The overall thrombosis rate was 14%, highest in renal-urinary (22.22%), digestive (21.35%). D-dimer was elevated in most cancer groups and significantly higher in patients with thrombosis. D-dimer showed the best predictive value in reproductive cancers (AUC for late stage = 0.8147; thrombosis = 0.7104), followed by respiratory cancers, moderate in digestive cancers and lowest in head and neck cancers.

Conclusion: D-dimer has predictive value for thrombosis and disease progression in cancer patients, particularly in reproductive cancers. Predictive performance varies across organ systems, suggesting a potential role for individualized use of D-dimer in risk assessment and monitoring of cancer patients.

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