Articles Vol. 67 No. 6 25/06/2026

ASSOCIATION BETWEEN HELICOBACTER PYLORI INFECTION AND COLORECTAL POLYPS

Tong Thi Phuong Anh1,2, Le Ngoc Lan Anh1,2, Nguyen Hoang Lan Anh1,2, Le Thanh Hieu1,2, Le Duy Khanh1,2, Nguyen Van Tuan1,2, Nguyen Thanh Liem1,2
1 Can Tho University of Medicine and Pharmacy
2 Trường Đại học Y Dược Cần Thơ
DOI: 10.52163/yhc.v67i6.5509
39 Views
0 Downloads
Keywords
Colorectal polyps, Helicobacter pylori.
Abstract

Objective: To determine the association between Helicobacter pylori infection and colorectal polyps at Can Tho University of Medicine and Pharmacy Hospital.

Methods: A cross-sectional descriptive study was conducted on 337 patients who underwent both upper gastrointestinal and endoscopy and colonoscopy at Can Tho University of Medicine and Pharmacy Hospital from October to December 2025. H.pylori infection was diagnosed using the urease test from gastric mucosal biopsy specimens. Colorectal polyps were confirmed by histopathological examination.

Results: The prevalence of H.pylori infection was 21.4%, and the prevalence of colorectal polyps was 30.4%. Polyps were more common in males than in females (37.7% vs 24.2%; OR = 1.900; p = 0.007) and in patients aged ≥ 40 years than in those under 40 years (33.7% vs 17.8%; OR = 2.347; p = 0.009). H.pylori infection was associated with an increased risk of colorectal polyps (45.8% vs. 26.0%; OR = 2.404; p = 0.001). Multivariate analysis identified male sex, age ≥ 40 years, and H.pylori infection as independent factors associated with colorectal polyps.

Conclusion: H.pylori infection, male sex, and age ≥ 40 years are independent risk factors for colorectal polyps, highlighting the importance of screening and early detection.

References
[1]
Sninsky J.A, Shore B.M, Lupu G.V, Crockett S.D. Risk factors for colorectal polyps and cancer. Gastrointest Endosc Clin N Am, 2022, 32 (2): 195-213. doi: 10.1016/j.giec.2021.12.008 Google Scholar
[2]
Kim J.H, Han H.W, Song J.H, Kim S.J, Kim Y.K, Kim H.J, Rhee T.G, Shim S.R. Increased risk of colorectal adenoma and benign colorectal polyp associated with Helicobacter pylori infection: a systematic review and meta-analysis. Transl Cancer Res, 2025, 14 (4): 2354-2366. doi: 10.21037/tcr-24-795 Google Scholar
[3]
Feng L, Zhao K, Wang G, Dong R, Zhang M, Xia S, Zhang Y, Zhou W, Tian D, Yan W, Liao J. Relationship between endoscopic gastric abnormalities and colorectal polyps: a cross-sectional study based on 33439 Chinese patients. Int J Med Sci, 2023, 20 (2): 219-224. doi: 10.7150/ijms.80543 Google Scholar
[4]
Lee K, Kim Y.H. Colorectal polyp prevalence according to alcohol consumption, smoking and obesity. Int J Environ Res Public Health, 2020, 17 (7): 2387. doi: 10.3390/ijerph17072387 Google Scholar
[5]
State-specific secondhand smoke exposure and current cigarette smoking among adults - United States, 2008. MMWR Morb Mortal Wkly Rep, 2009, 58 (44): 1232-1235. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5844a3.htm. Google Scholar
[6]
Bradley K.A, DeBenedetti A.F, Volk R.J, Williams E.C, Frank D, Kivlahan D.R. AUDIT-C as a brief screen for alcohol misuse in primary care. Alcohol Clin Exp Res, 2007, 31 (7): 1208-1217. doi: 10.1111/j.1530-0277.2007.00403.x Google Scholar
[7]
WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet, 2004, 363 (9403): 157-163. doi: 10.1016/s0140-6736(03)15268-3 Google Scholar
[8]
Liu Y, Li T, Lou L, Yang X, Kang C, Ren G, Zhang L, Zheng R, Kang X, Luo H, Liang S, Nie Y, Lv Y, Pan Y. Association between gastrointestinal lesions in individuals undergoing gastroscopy and colonoscopy simultaneously: a retrospective, observational study. BMC Gastroenterol, 2025, 25 (1): 403. doi: 10.1186/s12876-025-04012-9 Google Scholar
[9]
Basmaci N, Karataş A, Ergin M, Dumlu G. Association between Helicobacter pylori infection and colorectal polyps. Medicine (Baltimore), 2023, 102 (42): e35591. doi: 10.1097/md.0000000000035591 Google Scholar
[10]
Engelsberger V, Gerhard M, Mejías-Luque R. Effects of Helicobacter pylori infection on intestinal microbiota, immunity and colorectal cancer risk. Front Cell Infect Microbiol, 2024, 14: 1339750. doi: 10.3389/fcimb.2024.1339750. Google Scholar