Articles Vol. 63 No. Số tiếng Anh (2022) 08/12/2022

EFFECTS OF ANTHRACYCLINES ON LEFT VENTRICULAR FUNCTION ON BREAST CANCER PATIENTS

Vo Van Cuong1, Bui Dang Minh Tri2, Bui Khanh Toan3
1 Health Department of Phu Tan District
2 Pham Ngoc Thach University of Medicine
3 Tay Nguyen Institute of Hygiene and Epidemiology
Corresponding author: drtribui1@gmail.com
DOI: 10.52163/yhc.v63i9.550
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Keywords
Breast cancer, left ventricular function, Anthracyclines.
Abstract

Objective: To investigate the effect of Anthracyclines on left ventricular function on
breast cancer patients at Thong Nhat Hospital. Objects and methods: A prospective
descriptive study on 43 patients with breast cancer treated with Anthracyclines with
4 to 6 cycles as determined by the clinical doctor at Thong Nhat Hospital. Results:
Percentage of left ventricular ejection, total deformation of the vertical systolic stage
decreased significantly after treatment: EF before and after treatment were 60.23
± 3.46 and 59.44 ± 3,67 (%), respectively; GLS before and after treatment were
-20.01 ± 1.62 and -19.14 ± 1.82 (%), respectively. The incidence of cardiotoxicity
was 6.98%. The proportion of patients with subclinical left ventricular dysfunction
was 23.26%. After treatment, the proportion of respectively. The proportion of
patients with subclinical systolic dysfunction was higher in the decreased diastolic
function group compared to the group with normal diastolic function. Patients with
normal diastolic function after treatment decreased, the proportion of patients with
diastolic dysfunction increased significantly, accounting for 41.86% and 58.14%
No association was found between the type of anthracycline used, also disease
stage and the effect of anthracycline on left ventricular function. Conclusion: Left
ventricular ejection fraction, total deformation of the vertical systolic stage reduced.
The prevalence of cardiac toxicity and subclinical left ventricular dysfunction were
moderate. After treatment, the proportion of patients with normal diastolic function
decreased, the diastolic dysfunction increased. There was no relationship between the
type of Anthracycline used, also the disease stage and the effect of Anthracycline on
left ventricular function.

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