Articles Vol. 67 No. CĐ6-NCKH 16/06/2026

TOPICAL STEROID USE IN THE TREATMENT OF RHINOSINUSITIS IN PREGNANT WOMEN: A SCOPING REVIEW

Tran Ngoc Son1,2, Do Ba Hung3,4, Van Thu Huyen1,2, Hoang Thi Hoa Binh3,4
1 Bao Yen Regional Medical Center, Lao Cai
2 Trung tâm y tế khu vực Bảo Yên Lào Cai
3 Hanoi Medical University
4 Trường Đại học Y Hà Nội
DOI: 10.52163/yhc.v67iCD6.5336
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Keywords
Rhinosinusitis, pregnancy, topical steroids.
Abstract

Objective: To analyze the characteristics of studies on the use of topical steroids in the treatment of rhinosinusitis in pregnant women, and to describe the treatment outcomes and safety of topical steroid use during pregnancy.

Subjects and Methods: This scoping review included studies retrieved from electronic databases and information sources such as PubMed, Google Scholar, and the library of Hanoi Medical University. A total of 4 studies met the inclusion criteria and were included in the review.

Conclusion: Fluticasone propionate did not demonstrate a significant improvement in nasal congestion symptoms compared with placebo (p > 0.05). The use of intranasal fluticasone propionate during pregnancy did not affect adrenal function, with comparable S-cortisol and U-cortisol levels between the fluticasone and placebo groups (p > 0.05). Intranasal fluticasone propionate was shown to be safe for the fetus. Fetal growth parameters on ultrasound (femur length, biparietal diameter) and postnatal outcomes (gestational age at birth, birth weight, and Apgar score) did not differ significantly from those of the control group (p > 0.05).

References
[1]
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;58(Suppl S29):1-464. doi:10.4193/Rhin20.600 Google Scholar
[2]
Sedaghat AR. Chronic rhinosinusitis. Am Fam Physician. 2017;96(8):500-506. Google Scholar
[3]
Namazy JA, Schatz M. Current guidelines for the management of asthma during pregnancy. Immunol Allergy Clin North Am. 2006;26(1):93-102. doi:10.1016/j.iac.2005.10.003 IF: 2.2 Q3 B3 Google Scholar
[4]
Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S103-S115. doi:10.1016/j.jaci.2009.12.989 IF: 11.2 Q1 B1 Google Scholar
[5]
Schatz M, Zeiger RS. Diagnosis and management of rhinitis during pregnancy. Allergy Proc. 1988;9(5):545-554. doi:10.2500/108854188778965627 IF: 2.2 Q3 B3 Google Scholar
[6]
Namazy JA, Schatz M. Asthma and rhinitis during pregnancy. Mt Sinai J Med. 2011;78(5):661-670. doi:10.1002/msj.20284 IF: NA NA NA Google Scholar
[7]
Namazy JA, Schatz M. The safety of intranasal steroids during pregnancy: a good start. J Allergy Clin Immunol. 2016;138(1):105-106. doi:10.1016/j.jaci.2016.04.026 IF: 11.2 Q1 B1 Google Scholar
[8]
Bérard A, Sheehy O, Kurzinger ML, Juhaeri J. Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes. J Allergy Clin Immunol. 2016;138(1):97-104.e7. doi:10.1016/j.jaci.2016.01.021 Google Scholar
[9]
Ellegård EK, Hellgren M, Karlsson NG. Fluticasone propionate aqueous nasal spray in pregnancy rhinitis. Clin Otolaryngol Allied Sci. 2001;26(5):394-400. doi:10.1046/j.1365-2273.2001.00491.x Google Scholar
[10]
Mabry RL. Intranasal steroid injection during pregnancy. South Med J. 1980;73(9):1176-1179. doi:10.1097/00007611-198009000-00004 Google Scholar