Articles Vol. 67 No. CĐ6-NCKH 16/06/2026

SKIN TEST RESULTS IN PATIENTS SUSPECTED OF IMMEDIATE HYPERSENSITIVITY TO TAXANES AND PLATINUM AGENTS

Vu Thi Hang1,2, Chu Chí Hieu1,2, Nguyen Nhu Nguyet1,2, Bui Van Khanh1,2, Hoang Thi Hoat3,4
1 Clinical Allergy and Immunology Center, Bach Mai Hospital
2 Trung tâm Dị ứng – Miễn dịch lâm sàng, Bệnh viện Bạch Mai
3 Dermatology and Burn Department, Bach Mai Hospital
4 Khoa Da liễu và Bỏng, Bệnh viện Bạch Mai
DOI: 10.52163/yhc.v67iCD6.5333
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Keywords
Taxane, Platinum, skin prick test, intradermal tests, immediate hypersensitivity.
Abstract

Objectives: To evaluate skin test results in patients with suspected immediate hypersensitivity to Platinum agents and Taxanes.

Methods: A cross-sectional, retro-prospective descriptive study was conducted on patients with suspected immediate hypersensitivity to Taxanes or Platinum agents. The subjects were examined at the Allergen Department – Center for Allergology and Clinical Immunology over a 2-year period, from September 2023 to September 2025.

Results: The study included 102 patients who underwent 215 skin prick tests (SPT) and 108 intradermal tests (IDT). Only 16 patients yielded positive skin test results (10 SPTs and 6 IDTs) to either Platinum or Taxane agents. Among these, Oxaliplatin exhibited the highest rate of positive skin tests, while Docetaxel showed the lowest. No cross-reactivity between the agents was detected.

Conclusion: Skin tests in patients with suspected hypersensitivity to Platinum agents and Taxanes were predominantly negative. This supports the hypothesis that the underlying mechanism of chemotherapy-induced allergy is primarily non-IgE-mediated.

References
[1]
Lax T, Long A, Banerji A. Skin Testing in the Evaluation and Management of Carboplatin-Related Hypersensitivity Reactions. J Allergy Clin Immunol Pract. 2015;3(6):856-862. doi:10.1016/j.jaip.2015.07.003 Google Scholar
[2]
Tsao LR, Young FD, Otani IM, Castells MC. Hypersensitivity Reactions to Platinum Agents and Taxanes. Clin Rev Allergy Immunol. 2022;62(3):432-448. doi:10.1007/s12016-021-08877-y Google Scholar
[3]
Wang AL, Patil SU, Long AA, Banerji A. Risk-stratification protocol for carboplatin and oxaliplatin hypersensitivity: repeat skin testing to identify drug allergy. Annals of Allergy, Asthma & Immunology. 2015;115(5):422-428. doi:10.1016/j.anai.2015.07.017 Google Scholar
[4]
Levin AS, Slawski B, Camargo CA, Banerji A. Platin Risk Stratification Algorithm with Modified Intradermal Skin Test Protocol. J Allergy Clin Immunol Pract. 2020;8(3):1139-1141. doi:10.1016/j.jaip.2019.08.055 Google Scholar
[5]
Pagani M, Bavbek S, Alvarez-Cuesta E, et al. Hypersensitivity reactions to chemotherapy: an EAACI Position Paper. Allergy. 2022;77(2):388-403. doi:10.1111/all.15113 Google Scholar
[6]
Pagani M. The complex clinical picture of presumably allergic side effects to cytostatic drugs: symptoms, pathomechanism, reexposure, and desensitization. Med Clin North Am. 2010;94(4):835-852, xiii. doi:10.1016/j.mcna.2010.03.002 Google Scholar
[7]
Pagani M, Bavbek S, Dursun AB, et al. Role of Skin Tests in the Diagnosis of Immediate Hypersensitivity Reactions to Taxanes: Results of a Multicenter Study. J Allergy Clin Immunol Pract. 2019;7(3):990-997. doi:10.1016/j.jaip.2018.09.018 Google Scholar
[8]
Thomas RR, Quinn MG, Schuler B, Grem JL. Hypersensitivity and idiosyncratic reactions to oxaliplatin. Cancer. 2003;97(9):2301-2307. doi:10.1002/cncr.11379 Google Scholar
[9]
Picard M, Castells MC. Re-visiting Hypersensitivity Reactions to Taxanes: A Comprehensive Review. Clin Rev Allergy Immunol. 2015;49(2):177-191. doi:10.1007/s12016-014-8416-0 Google Scholar
[10]
Leguy-Seguin V, Jolimoy G, Coudert B, et al. Diagnostic and predictive value of skin testing in platinum salt hypersensitivity. J Allergy Clin Immunol. 2007;119(3):726-730. doi:10.1016/j.jaci.2006.11.640 Google Scholar
[11]
Prieto García A, Pineda de la Losa F. Immunoglobulin E-mediated severe anaphylaxis to paclitaxel. J Investig Allergol Clin Immunol. 2010;20(2):170-171. Google Scholar
[12]
Madrigal-Burgaleta R, Berges-Gimeno MP, Angel-Pereira D, et al. Hypersensitivity and desensitization to antineoplastic agents: outcomes of 189 procedures with a new short protocol and novel diagnostic tools assessment. Allergy. 2013;68(7):853-861. doi:10.1111/all.12105 Google Scholar
[13]
Picard M, Pur L, Caiado J, et al. Risk stratification and skin testing to guide re-exposure in taxane-induced hypersensitivity reactions. J Allergy Clin Immunol. 2016;137(4):1154-1164.e12. doi:10.1016/j.jaci.2015.10.039 Google Scholar