Articles Vol. 67 No. CĐ6-NCKH 16/06/2026

OUTCOMES OF MOSAIC EMBRYO TRANSFER AT THE NATIONAL CENTER FOR ASSISTED REPRODUCTIVE TECHNOLOGY

Nguyen Thi Thanh Lam1,2, Nguyen Thi Thu Ha1,2,3,4, Dang Hong Hai1,2, Nguyen Viet Quang3,4, Ho Sy Hung3,4,5,6, Duong Thi Tra Giang3,4, Dang Thu Hang3,4, Kieu Manh Hung3,4, Truong Quang Vinh1,2, Mac Thi My Linh7,8
1 University of Medicine and Pharmacy, Vietnam National University, Hanoi
2 Trường Đại học Y Dược, Đại học Quốc gia Hà Nội
3 National Hospital of Obstetrics and Gynecology
4 Bệnh viện Phụ Sản Trung ương
5 Hanoi Medical University
6 Trường Đại học Y Hà Nội
7 Phenikaa University Hospital
8 Bệnh viện Đại học Phenikaa
DOI: 10.52163/yhc.v67iCD6.5326
18 Views
0 Downloads
Keywords
Mosaic embryos transfer, PGT-A, IVF.
Abstract

Objective: To evaluate the outcomes of mosaic embryo transfer at the National Center for Assisted Reproductive, National Hospital of Obstetrics and Gynecology in 2024.

Subjects and methods: A retrospective study was conducted on 33 patients who underwent mosaic embryo transfer at the National Center for Assisted Reproductive, from January to December 2024.

Results: The study population consisted of a clinically complex group, with 48.48% of patients ≥ 35 years. Ovarian stimulation demonstrated favorable outcomes, yielding an average of 7.76 ± 5.78 blastocysts. The ongoing pregnancy rate reached 30.3%, which was higher than that reported in several international studies, indicating the effectiveness of the embryo selection strategy. All live-born infants were delivered at term with normal birth weights (≥ 2500gr), confirming neonatal safety. These findings provide important real-world evidence to support the development and optimization of mosaic embryo transfer protocols in Vietnam.

Conclusions: Mosaic embryo transfer represents a feasible and safe treatment option in cases where no euploid embryos are available. The degree and characteristics of mosaicism are key prognostic factors that should be carefully considered when developing embryo selection strategies.

References
[1]
Nakhuda G et al. Frequencies of chromosome-specific mosaicisms in trophoectoderm biopsies detected by next-generation sequencing. Fertil Steril, 2018, 109 (5): 857-865. doi: 10.1016/j.fertnstert.2018.01.011 Google Scholar
[2]
Lee C.I et al. Healthy live births from transfer of low-mosaicism embryos after preimplantation genetic testing for aneuploidy. J Assist Reprod Genet, 2020, 37 (9): 2305-2313. doi: 10.1007/s10815-020-01876-6. Google Scholar
[3]
Taylor T.H et al. The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans. Hum Reprod Update, 2014, 20 (4): 571-581. doi: 10.1093/humupd/dmu016. Google Scholar
[4]
Munné S et al. Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos. Reprod Biomed Online, 2007, 14 (5): 628-634. doi: 10.1016/S1472-6483(10)61057-7. Google Scholar
[5]
Campos G et al. Blastocoel fluid as an alternative source of DNA for minimally invasive PGT and biomarker of embryo competence. Reprod Biomed Online, 2024, 49 (4): 104322. doi: 10.1016/j.rbmo.2024.104322. Google Scholar
[6]
Treff N.R et al. The “mosaic” embryo: misconceptions and misinterpretations in preimplantation genetic testing for aneuploidy. Fertil Steril, 2021, 116 (5): 1205-1211. doi: 10.1016/j.fertnstert.2021.06.027 Google Scholar
[7]
Viotti M et al. Chromosomal, gestational, and neonatal outcomes of embryos classified as a mosaic by preimplantation genetic testing for aneuploidy. Fertil Steril, 2023, 120 (5): 957-966. doi: 10.1016/j.fertnstert.2023.07.022 Google Scholar
[8]
Spinella F et al. Extent of chromosomal mosaicism influences the clinical outcome of in vitro fertilization treatments. Fertil Steril, 2018, 109 (1): 77-83. doi: 10.1016/j.fertnstert.2017.09.025 Google Scholar
[9]
Morales R et al. Perinatal and postnatal outcomes up to the third year of life after the transfer of mosaic embryos compared with euploid embryos. Fertil Steril, 2024, 122 (3): 537-539. doi: 10.1016/j.fertnstert.2024.04.040 Google Scholar
[10]
Phạm Thị Anh và cộng sự. Kết cục thai kỳ trên những trường hợp chuyển phôi thể khảm và một số yếu tố liên quan tại Bệnh viện Đa khoa Tâm Anh Hà Nội, 2021-2023. Tạp chí Y học dự phòng, 2024, 34 (2): 94-100. doi: 10.51403/0868-2836/2024/1627. Google Scholar