Articles Vol. 63 No. chuyên đề 3-HN Sản Nhi Nghệ An (2022) 30/11/2022

RELATIONSHIP BETWEEN SPERM DNA FRAGMENTATION INDEX AND CONVENTIONAL SEMEN PARAMETERS IN MALE PATIENTS WITH INFERTILITY

Le Ngoc Tue Nhi1,2, Truong Quoc Phong1,2, Nguyen Thi Tuyet Mai3,4, Le Quy Thuong3,4, Pham Thai Ha3,4, Doan Xuan Kien3,4
1 Phu Tho Obstetrics & Pediatrics Hospital
2 Bệnh viện Sản Nhi Phú Thọ
3 Hanoi University of Science and Technology
4 Trường Đại học Bách Khoa Hà Nội
Corresponding author: lengoctuenhi1001@gmail.com
DOI: 10.52163/yhc.v63i8.521
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Keywords
Halosperm, Sperm DNA fragmentation, infertile men, Sperm chromatin dispersion test.
Abstract

Objectives: To determine the relationship between sperm chromatin dispersion test (SCD)
parameters (DNA fragmentation index - DFI) and conventional semen parameters in male patients
with infertility.
Subjects and methods: A cross-sectional descriptive study was performed on 150 semen
samples of male patients by masturbation at the Center for Assisted Reproduction and Andrology -
Phu Tho Obstetrics & Pediatrics Hospital. Evaluation of semen parameters according to WHO
(2021) and determination of sperm DNA fragmentation index by SCD method.
Results: A significant negative association between DFI with: Sperm density (r = -0.405,
p<0.001), Sperm Mobility (r = - 0.30 và p < 0.001), Vitality (r = - 0.31 và p < 0.001), Sperm
Morphology (r = -0.456 và p = <0.001). There is no difference in the degree of sperm
fragmentation by age, time to abstain from ejaculation, ejaculate volume, pH.
Conclusion: SCD Parameters had a significant negative association with: Sperm density,
Mobility Sperm, Vitality, Sperm Morphology. No correlation was found between DFI-SCD with:
Age, time to abstain from ejaculation, pH.

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