Articles Vol. 63 No. chuyên đề 3-HN Sản Nhi Nghệ An (2022) 30/11/2022

TREATMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY BY APPLYING OF THERAPEUTIC HYPOTHERMIA AT CAMAU OBSTETRICS-PEDIATRIC HOSPITAL FROM 2017 TO 2022

Vo Phi Au1,2, Pham Minh Pha1,2, Phan Viet Son1,2
1 Ca Mau Hospital of Obstetrics and Pediatrics
2 Bệnh viện Sản Nhi Sản Nhi Cà Mau
Corresponding author: vophiau@gmail.com
DOI: 10.52163/yhc.v63i8.520
16 Views
0 Downloads
Keywords
Sơ sinh, bệnh não do thiếu oxy – thiếu máu cục bộ.
Abstract

Objective: To evaluate treatment results of neonatal hypoxic ischemic encephalopathy (HIE)
by applying of therapeutic hypothermia at Camau Obstetrics and Pediatrics Hospital from 2017 to
2022.
Method: Cross sectional. 23 HIE newborns were indicated for treatment by therapeutic
hypothermia at Camau Obstetrics and Pediatrics Hospital from 2017 to 2022.
Results: In 23 HIE newborn, male accounted for 78.3%, severe HIE accounted for 48.8%, the
average age at onset of therapeutic hypothermia was 165.0 ± 88.3 minutes; during procedure
56.5% of newborn had convulsions; 26.1% had PH < 7.2; 13.0% had heart rate less 100 beats per
min, hyperglycemia requiring insulin-therapy; 8.7% had coagulation disorders, platelets less
100,000 per microliter. The mortality rate accounted for 17.4%; Infants with psychomotor
retardation recorded at 12 months old were 20.0%; at 18 months old were 16.7%.
Conclusion: Hypothermia is significant in the treatment of moderate-severe HIE, contributing
to the reduction of mortality and cerebral sequelae.

References
[1]
Akisu M, “Selective head cooling with Google Scholar
[2]
hypothermia suppresses the generation of Google Scholar
[3]
platelet-activating factor in cerebrospinal fluid Google Scholar
[4]
of newborn infants with perinatal asphyxia”. Google Scholar
[5]
Prostaglandins Leukot Essent Fatty Acids Google Scholar
[6]
,pp. 45–50, 2003. Google Scholar
[7]
Bryce J, Boschi-Pinto C, Shibuya K et al., Google Scholar
[8]
“WHO estimates of the causes of death in Google Scholar
[9]
children”, Lancet, 365(9465), pp. 1147-52, Google Scholar
[10]
Jacobs SE, “Cooling for newborns with Google Scholar
[11]
hypoxic ischaemic encephalopathy”, Cochrane Google Scholar
[12]
Database Syst Rev, 31(1):CD003311, pp. 1 – Google Scholar
[13]
, 2013. Google Scholar
[14]
Li C, “Prenatal and neonatal risk factors Google Scholar
[15]
for perinatal arterial ischaemic stroke: a Google Scholar
[16]
systematic review and meta-analysis”, Eue J N Google Scholar
[17]
eurol, 24(8), pp. 1006-1015, 2017. Google Scholar
[18]
Lawn JE, “Lancet Neonatal Survival Google Scholar
[19]
Steering Team (2005), 4 million neonatal Google Scholar
[20]
deaths: when? Where? Why?”, Lancet. Google Scholar
[21]
(9462): pp. 891-900. Google Scholar
[22]
Lin ZL, “Mild hypothermia via selective Google Scholar
[23]
head cooling as neuroprotective therapy in term Google Scholar
[24]
neonates with perinatal asphyxia: an experience Google Scholar
[25]
from a single neonatal intensive care unit”. J Google Scholar
[26]
Perinatol 26: 180–184, 2006. Google Scholar
[27]
Robertson NJ, “Therapeutic hypothermia Google Scholar
[28]
for birth asphyxia in low-resource settings: a Google Scholar
[29]
pilot randomised controlled trial”, Lancet Google Scholar
[30]
(9641): 801–3, 2008. Google Scholar
[31]
Thayyil S, “WholeBody Cooling in Google Scholar
[32]
Neonatal Encephalopathy using Phase Google Scholar
[33]
Changing Material”, Arch Dis Childhood, 2010 Google Scholar
[34]
(in press). Google Scholar
[35]
Zhou WH, “Selective head cooling with Google Scholar
[36]
mild systemic hypothermia after neonatal Google Scholar
[37]
hypoxic-ischemic encephalopathy: a Google Scholar
[38]
multicenter randomized controlled trial in Google Scholar
[39]
china”. J Pediatr 157: 367–372, 2010. Google Scholar