Articles Vol. 67 No. 5 25/05/2026

ASSESSEMENT OF POSTOPERATIVE COMPLICATION RATE AND ASSOCIATED FACTORS FOLLOWING HEPATECTOMY FOR HEPATOCELLULAR CARCINOMA

Luong Duy Truong1,2, Huynh Thanh Long3,4,5,6
1 Pham Ngoc Thach University of Medicine
2 Trường Đại học Y khoa Phạm Ngọc Thạch
3 Nguyen Tri Phuong Hospital
4 Nguyen Tat Thanh University
5 Bệnh viện Nguyễn Tri Phương
6 Trường Đại học Nguyễn Tất Thành
DOI: 10.52163/yhc.v67i5.5125
24 Views
10 Downloads
Abstract

Objective: To determine the rate of postoperative complications and associated factors in hepatectomy for hepatocellular carcinoma (HCC).

Materials and Methods: A retrospective cross-sectional study was conducted on 95 patients with HCC who underwent hepatectomy at Binh Dan Hospital from January 2022 to July 2025. Preoperative liver function was assessed using the Child–Pugh classification, ALBI score, and MELD score. Postoperative complications and associated factors were statistically analyzed.

Results: The overall postoperative complication rate was 29.5%. Factors significantly associated with complications included comorbidities (p=0.048), previous hepatectomy (p=0.037), open surgery (p=0.046), operative time >180 minutes (p=0.003), and blood loss ≥500 mL (p=0.002). Higher ALBI and MELD scores showed a trend toward increased risk of complications.

Conclusion: Hepatectomy for HCC demonstrated an acceptable complication rate. Postoperative complications were associated with comorbidities and surgical factors, particularly prolonged operative time and increased blood loss. ALBI and MELD scores may assist in preoperative liver function assessment.

References
[1]
IARC. Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer; Year. Available from: https://gco.iarc.fr Google Scholar
[2]
Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, et al. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg. 2002;236(4):397-407. Google Scholar
[3]
Tsilimigras DI, Sahara K, Moris D, Mehta R, Paredes AZ, Bagante F, et al. Trends in postoperative outcomes after hepatic resection: an analysis of 12,000+ patients from a multi-institutional database. J Gastrointest Surg. 2019;23(5):1007-1017. Google Scholar
[4]
Li C, Wen TF, Yan LN, Li B, Wang WT, Yang JY, et al. Risk factors associated with postoperative complications after hepatectomy for hepatocellular carcinoma. Hepatogastroenterology. 2011;58(112):2139-2144. Google Scholar
[5]
Teh SH, Nagorney DM, Stevens SR, Offord KP, Therneau TM, Plevak DJ, et al. Risk factors for mortality after surgery in patients with cirrhosis. Gastroenterology. 2007;132(4):1261-1269. Google Scholar
[6]
Northup PG, Wanamaker RC, Lee VD, Adams RB, Berg CL. Model for End-Stage Liver Disease (MELD) predicts nontransplant surgical mortality in patients with cirrhosis. Ann Surg. 2005;242(2):244-251. Google Scholar
[7]
Rahbari NN, Koch M, Mehrabi A, Weitz J, Büchler MW. Repeat hepatectomy for recurrent hepatocellular carcinoma: a multicenter analysis. Ann Surg Oncol. 2011;18(3):650-657. Google Scholar
[8]
Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, et al. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach—the ALBI grade. J Clin Oncol. 2015;33(6):550-558. Google Scholar
[9]
Hyder O, Pulitano C, Firoozmand A, Dodson R, Wolfgang CL, Choti MA, et al. A risk model to predict postoperative liver failure after major hepatectomy. J Am Coll Surg. 2013;216(4):691-699. Google Scholar
[10]
Van den Broek MA, Olde Damink SW, Dejong CH, Lang H, Malagó M, Jalan R, et al. Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment. Ann Surg. 2008;247(5):767-780. Google Scholar