Articles Vol. 67 No. CĐ5-NCKH 04/05/2026

SLEEP DISTURBANCES AMONG PATIENTS WITH ALZHEIMER’S DISEASE BY THE SLEEP-50 SCALE AT THE NATIONAL INSTITUTE OF MENTAL HEALTH, BACH MAI HOSPITAL

Nguyen Van Tuan1,2,3,4, Luong Thi Mai Loan5,6, Nguyen Kim Anh1,2,3,4, Pham Thi Thu Hien1,3, Bui Van Loi1,3
1 Bach Mai Hospital
2 Hanoi Medical University
3 Bệnh viện Bạch Mai
4 Trường Đại học Y Hà Nội
5 Hai Phong University of Medicine and Pharmacy
6 Trường Đại học Y dược Hải Phòng
DOI: 10.52163/yhc.v67iCD5.5024
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Keywords
Alzheimer’s disease, sleep disorders, Sleep-50, insomnia, circadian rhythm disorder.
Abstract

Objective: To describe the prevalence, patterns, and related factors sleep disturbances using the Sleep-50 scale in patients with Alzheimer’s disease (AD) receiving treatment at the National Institute of Mental Health.

Subjects and methods: A cross-sectional descriptive study was conducted on 103 patients diagnosed with Alzheimer’s disease according to ICD-10 criteria. Sleep disturbances were evaluated using the Sleep‑50 questionnaire, covering nine sleep‑related domains.

Results: Based on the Sleep 50, sleep disturbances were identified in 78.6% of participants. The most common disorders were insomnia (86,4%), sleep apnea (22,2%), and circadian rhythm disorder (18,5%).  Among those with insomnia, difficulty maintaining sleep was the most frequent symptom (85,7%). Sleep disturbance was significantly associated with later-onset AD (OR=6,12; 95% CI: 2,22–16,89; p<0,001) and moderate–severe dementia (OR=4,8; 95%CI: 1,7–13,5; p<0,05).

Conclusion: Sleep disorders are highly prevalent among Alzheimer’s disease patients, with insomnia being the most common. Sleep disturbance severity increases with age and cognitive decline. Early identification and management of sleep problems are essential to improve patients’ quality of life and support caregivers.

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