Articles Vol. 67 No. CĐ5-NCKH 04/05/2026

CHARACTERISTICS OF METABOLIC SYNDROME IN PATIENTS WITH KNEE OSTEOARTHRITIS AT THE MUSCULOSKELETAL CENTER OF VO TRUONG TOAN UNIVERSITY HOSPITAL

Tran Viet Ha1,2, Nguyen Hung Tran1,2
1 Vo Truong Toan University
2 Trường Đại học Võ Trường Toản
DOI: 10.52163/yhc.v67iCD5.4987
23 Views
6 Downloads
Keywords
Diabetes mellitus, metabolic syndrome, hypertension, knee osteoarthritis.
Abstract

Objectives: To determine the prevalence of metabolic syndrome and its association with the severity of primary knee osteoarthritis.

Subjects and methods: A cross-sectional descriptive study was conducted on 160 outpatients with primary knee osteoarthritis at the Musculoskeletal Center, Vo Truong Toan University Hospital. Knee osteoarthritis was diagnosed according to the American College of Rheumatology criteria, and metabolic syndrome was defined based on the IDF 2005 criteria.

Results: Metabolic syndrome was present in 73.1% of patients and was significantly associated with severe radiographic knee osteoarthritis (OR = 5.46; p = 0.002). Obesity (OR = 6.12; p < 0.001) and increased waist circumference (OR = 3.8; p < 0.001) were also strongly associated with radiographic severity. The prevalence of bilateral knee osteoarthritis increased with the number of metabolic syndrome components, reaching the highest level in patients with 3 or more components (OR = 5.3; p < 0.001).

Conclusions: Metabolic syndrome and its components, particularly obesity and increased waist circumference, are closely associated with the severity of knee osteoarthritis, highlighting the importance of screening and controlling metabolic risk factors in the management of knee osteoarthritis.

References
[1]
Ho Pham L.T, Lai T.Q et al. Prevalence of radiographic osteoarthritis of the knee and its relationship to pain. PLoS One, 2014, 9 (4): e94563. doi: 10.1371/journal.pone.0094563. Google Scholar
[2]
Trương Thiện Ân, Trần Quốc Cường và cộng sự. Mối liên quan giữa hội chứng chuyển hóa và mức độ nặng thoái hóa khớp gối trên X quang. Tạp chí Y học Việt Nam, 2022, 512 (2): 45-52. doi: 10.51298/vmj.v512i2.2223 Google Scholar
[3]
Puenpatom R.A, Victor T.W. Increased prevalence of metabolic syndrome in individuals with osteoarthritis: an analysis of NHANES data. Postgraduate Medicine, 2009, 121 (6): 9-20. doi: 10.3810/pgm.2009.11.2073 Google Scholar
[4]
Nguyễn Thị Thanh Mai, Lê Hoàng Minh, Phạm Văn Hùng. Đặc điểm lâm sàng, X quang và hội chứng chuyển hóa ở bệnh nhân thoái hóa khớp gối nguyên phát. Tạp chí Y Dược học, 2019, 39 (4): 23-30. Google Scholar
[5]
Dahaghin S, Bierma-Zeinstra S.M.A et al. Prevalence and determinants of knee osteoarthritis in the elderly population: the Rotterdam Study. Arthritis & Rheumatism, 2009, 60 (2): 333-341. doi: 10.1002/art.24236 Google Scholar
[6]
Vasilic-Brasnjevic S, Marinkovic J et al. Association of central obesity and knee osteoarthritis severity. Clinical Rheumatology, 2016, 35 (8): 2039-2046. doi: 10.1007/s10067-016-3269-7 Google Scholar
[7]
Zhang Y, Jordan J.M. Epidemiology of osteoarthritis. Clinics in Geriatric Medicine, 2010, 26 (3): 355-369. doi: 10.1016/j.cger.2010.03.001 Google Scholar
[8]
Jungmann P.M, Baum T et al. Association of metabolic risk factors with cartilage degeneration assessed by MRI T2 relaxation time. Osteoarthritis and Cartilage, 2013, 21 (5): 653-660. doi: 10.1016/j.joca.2013.02.002 Google Scholar
[9]
Abourazzak F.E, Talbi S et al. Metabolic syndrome in patients with knee osteoarthritis. Pan African Medical Journal, 2015, 21: 257. doi: 10.11604/pamj.2015.21.257.6534 Google Scholar