Articles Vol. 63 No. chuyên đề 2-HN Y học Giới tính (2022) 18/11/2022

OVERVIEW OF DIAGNOSIS AND TREATMENT OF FEMALE HYPOACTIVE SEXUAL DESIRE DISORDER

Pham Minh Ngoc1,2, Nguyen Quang3,4
1 Andrology and Fertility Hospital of Hanoi
2 Bệnh viện Nam học và hiếm muộn Hà Nội
3 Viet Duc University Hospital
4 Bệnh viện Hữu nghị Việt Đức
Corresponding author: bsngocnamkhoa@gmail.com
DOI: 10.52163/yhc.v63i7.492
33 Views
0 Downloads
Keywords
Female sexual dysfunction, female hypoactive sexual desire disorder.
Abstract

Background: Female sexual dysfunction has only been studied from a modern perspective
for more than six decades and is evolving rapidly [1]. “Female hypoactive sexual desire
disorder” was first reported in the DSM-III 41 years ago [2], however, so far the understanding
of physiology, pathogenesis, diagnosis, and treatment is still limited.
Aim: To develop an overview of the diagnosis, approach, and treatment of female hypoactive
sexual desire disorder.
Methods: Synthesis and analysis of studies on female hypoactive sexual desire disorder
and the latest guidelines on diagnosis and treatment of the International Society for the
Study of Women’s Sexual Health, the International Consultation on Sexual Medicine, The
International Society for Sexual Medicine.
Results: Complete an update on the diagnosis and treatment of female hypoactive sexual
desire disorder.
Conclusions: The Decreased Sexual Desire Screener is essential to screen for female
hypoactive sexual desire disorder. Asking about the disease, and exploiting psychological,
physiological, relationship, and social factors are extremely important for diagnosis and
treatment orientation. The treatment of female hypoactive sexual desire disorder may engage
both psychosocial and biological strategies. This review aims is to develop an overview of
the diagnosis, approach, and treatment of female hypoactive sexual desire disorder.

References
[1]
Irwin Goldstein, Women’s Sexual Function Google Scholar
[2]
and Dysfunction Study, Diagnosis and Google Scholar
[3]
Treatment, pp 3, 2005. Google Scholar
[4]
American Psychiatric Association, DSM‐ Google Scholar
[5]
III: Diagnostic and Statistical Manual of Google Scholar
[6]
Mental Disorders, 3rd edn. Washington, DC: Google Scholar
[7]
American Psychiatric Association, 1980. Google Scholar
[8]
Irwin Goldstein, Textbook of Female Sexual Google Scholar
[9]
Function and Dysfunction: Diagnosis and Google Scholar
[10]
Treatment, John Wiley & Sons, Hoboken, Google Scholar
[11]
Shifren JL, Monz BU, Russo PA et al., Google Scholar
[12]
Sexual problems and distress in United Google Scholar
[13]
States women: prevalence and correlates. Google Scholar
[14]
Obstet Gynecol; 112(5):970–978, 2008. Google Scholar
[15]
Dennerstein L, Koochaki P, Barton I et Google Scholar
[16]
al., Hypoactive sexual desire disorder in Google Scholar
[17]
menopausal women: A survey of Western Google Scholar
[18]
European women. J Sex Med; 3:212–222, Google Scholar
[19]
Leiblum S, Symonds T, Moore J et al., A Google Scholar
[20]
methodology study to develop and validate Google Scholar
[21]
a screener for hypoactive sexual desire Google Scholar
[22]
disorder in postmenopausal women. J Sex Google Scholar
[23]
Med;3:455-464, 2006. Google Scholar
[24]
Clayton AH, Goldfischer ER, Goldstein I Google Scholar
[25]
et al., Validation of the Decreased Sexual Google Scholar
[26]
Desire Screener (DSDS): a brief diagnostic Google Scholar
[27]
instrument for generalized acquired female Google Scholar
[28]
hypoactive sexual desire disorder (HSDD). J Google Scholar
[29]
Sex Med 2009;6:730-738, 2009. Google Scholar
[30]
Clayton AH, Goldstein I, Kim NN et al., Google Scholar
[31]
The International Society for the Study of Google Scholar
[32]
Women’s Sexual Health Process of Care for Google Scholar
[33]
Management of Hypoactive Sexual Desire Google Scholar
[34]
Disorder in Women. Mayo Clin Proc. 2018 Google Scholar
[35]
Apr;93(4):467-487, 2018. Google Scholar
[36]
Khera M, Testosterone therapy for female Google Scholar
[37]
sexual dysfunction. (2015). Sex Med Rev; Google Scholar
[38]
:137. Google Scholar
[39]
Stahl SM, Sommer B, Allers KA, Google Scholar
[40]
Multifunctional pharmacology of flibanserin: Google Scholar
[41]
possible mechanism of therapeutic action Google Scholar
[42]
in hypoactive sexual desire disorder. J Sex Google Scholar
[43]
Med;8(1):15-27, 2011. Google Scholar
[44]
Katz M, DeRogatis LR, Ackerman R et al., Google Scholar
[45]
BEGONIA Trial Investigators. Efficacy of Google Scholar
[46]
flibanserin in women with hypoactive sexual Google Scholar
[47]
desire disorder: results from the BEGONIA Google Scholar
[48]
trial. J Sex Med;10(7):1807-1815, 2013. Google Scholar
[49]
Thorp J, Simon J, Dattani D et al., DAISY Google Scholar
[50]
Trial Investigators. Treatment of hypoactive Google Scholar
[51]
sexual desire disorder in premenopausal Google Scholar
[52]
women: efficacy of flibanserin in the DAISY Google Scholar
[53]
study. J Sex Med;9(3):793-804, 2012. Google Scholar
[54]
Derogatis LR, Komer L, Katz M et al., Google Scholar
[55]
VIOLET Trial Investigators. Treatment Google Scholar
[56]
of hypoactive sexual desire disorder Google Scholar
[57]
in premenopausal women: efficacy of Google Scholar
[58]
flibanserin in the VIOLET Study. J Sex Google Scholar
[59]
Med;9(4):1074-1085, 2012. Google Scholar
[60]
ADDYI (flibanserin) [package insert]. Google Scholar
[61]
Bridgewater, NJ: Sprout Pharmaceuticals, Google Scholar
[62]
Kingsberg SA, Clayton AH, Pfaus JG, The Google Scholar
[63]
female sexual response: current models, Google Scholar
[64]
neurobiological underpinnings and agents Google Scholar
[65]
currently approved or under investigation Google Scholar
[66]
for the treatment of hypoactive sexual desire Google Scholar
[67]
disorder. CNS Drugs; 29(11):915-933, 2015. Google Scholar
[68]
Goldstein I, Kim NN, Clayton AH et Google Scholar
[69]
al., Hypoactive Sexual Desire Disorder: Google Scholar
[70]
International Society for the Study of Google Scholar
[71]
Women’s Sexual Health (ISSWSH) Expert Google Scholar
[72]
Consensus Panel Review. Mayo Clin Google Scholar
[73]
Proc;92(1):114-128, 2017. Google Scholar
[74]
Wierman ME, Arlt W, Basson R et al., Google Scholar
[75]
Androgen therapyin women: a reappraisal: Google Scholar
[76]
an Endocrine Society clinical practice Google Scholar
[77]
guideline. J Clin Endocrinol Metab; Google Scholar
[78]
:3489, 2014. Google Scholar
[79]
Nastri CO, Lara LA, Ferriani RA et al., Google Scholar
[80]
Hormone therapy for sexual function Google Scholar
[81]
in perimenopausal and postmenopausal Google Scholar
[82]
women. Cochrane Database Syst Google Scholar
[83]
Rev;(6):CD009672, 2013. Google Scholar
[84]
Poels S, Bloemers J, van Rooij K et al., Google Scholar
[85]
Toward personalized sexual medicine (part Google Scholar
[86]
: testosterone combined with a PDE5 Google Scholar
[87]
inhibitor increases sexual satisfaction in Google Scholar
[88]
women with HSDD and FSAD, and a low Google Scholar
[89]
sensitive system for sexual cues. J Sex Google Scholar
[90]
Med;10:810-823, 2013. Google Scholar
[91]
Kingsberg SA, Clayton AH, Portman D Google Scholar
[92]
et al., Bremelanotide for the Treatment Google Scholar
[93]
of Hypoactive Sexual Desire Disorder: Google Scholar
[94]
Two Randomized Phase 3 Trials. Obstet Google Scholar
[95]
Gynecol;134(5):899-908, 2019. Google Scholar