Articles Vol. 67 No. CĐ4-HN Ký sinh trùng-HN Hóa sinh 2026 21/04/2026

CLINICAL CHARACTERISTICS AND ANTIBIOTIC RESISTANCE PHENOTYPES OF KLEBSIELLA PNEUMONIAE ISOLATED AT XUYEN A GENERAL HOSPITAL IN 2025

Nguyen Huu Ngoc Tuan1,2, Phan Van Tung3,4
1 Center for Biomedical Testing and Research, Pham Ngoc Thach University of Medicine
2 Trung tâm Xét nghiệm và Nghiên cứu Y sinh, Trường Đại học Y khoa Phạm Ngọc Thạch
3 Department of Laboratory, Xuyen A General Hospital
4 Khoa Xét nghiệm, Bệnh viện Đa khoa Xuyên Á
DOI: 10.52163/yhc.v67iCD4.4873
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Keywords
Klebsiella pneumoniae, Carbapenem resistance, multidrug resistance, resistance phenotype.
Abstract

Objectives: To investigate the clinical characteristics and antibiotic resistance phenotypes of Klebsiella pneumoniae isolated at Xuyen A General Hospital, Ho Chi Minh city, period January-June 2025.

Methods: A cross-sectional descriptive study was conducted on 50 non-duplicate K.pneumoniae isolates from clinical specimens. Identification was performed using biochemical methods on the VITEK 2 Compact system, with molecular confirmation by real-time PCR using the ZKIR primer pair. Antimicrobial susceptibility testing was performed by automated broth microdilution and interpreted according to CLSI M100 Ed.35 (2025).

Results: The mean patient age was 62.7 ± 12.6 years, with equal sex distribution. The most common comorbidities were hypertension (58%) and diabetes mellitus (54%). Urine was the predominant specimen type (44%), and 86% of isolates were community-acquired. All isolates (100%) were resistant to Ampicillin. Carbapenem resistance was detected in 48% of isolates; multidrug resistance (MDR) in 68%; extensive drug resistance (XDR) in 54%; and ESBL production in 18%. Gentamicin was the only antibiotic retaining a high susceptibility rate (74%).

Conclusion: K.pneumoniae isolates at Xuyen A General Hospital showed alarming rates of Carbapenem resistance and multidrug resistance. These findings provide the first local microbiological data to support empirical antibiotic therapy at this institution.

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