Articles Vol. 67 No. CĐ4-HN Ký sinh trùng-HN Hóa sinh 2026 21/04/2026

COMPARISON OF THE DISCRIMINATIVE PERFORMANCE OF FRAX AND GARVAN MODELS FOR ASSESSING FRACTURE RISK IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS

Cao Dinh Hung1,2,3,4, Tran Quang Khanh2,4,5,6, Nguyen Dinh Thong7,8, Vo Chau Duyen9,10
1 Pham Ngoc Thach University of Medicine
2 Endocrinology Department, Nguyen Tri Phuong Hospital
3 Trường Đại học Y khoa Phạm Ngọc Thạch
4 Khoa Nội tiết, Bệnh viện Nguyễn Tri Phương
5 University of Medicine and Pharmacy at Ho Chi Minh city
6 Đại học Y Dược thành phố Hồ Chí Minh
7 Musculoskeletal Department, Nguyen Tri Phuong Hospital
8 Khoa Cơ xương khớp, Bệnh viện Nguyễn Tri Phương
9 Orthopedic Trauma Department, Nguyen Tri Phuong Hospital
10 Khoa Chấn thương chỉnh hình, Bệnh viện Nguyễn Tri Phương
DOI: 10.52163/yhc.v67iCD4.4855
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Keywords
Osteoporotic fracture, type 2 diabetes mellitus, postmenopausal women, FRAX, GARVAN.
Abstract

Objectives: To investigate the prevalence of osteoporotic fractures and to compare the discriminative performance of the FRAX and GARVAN models in assessing fracture risk among postmenopausal women with type 2 diabetes mellitus in Vietnam.

Methods: A descriptive cross-sectional study was conducted in 94 postmenopausal women with type 2 diabetes mellitus who attended the Departments of Endocrinology, Musculoskeletal, and Orthopedic Trauma at Nguyen Tri Phuong Hospital between August 2025 and January 2026.

Results: The median age of the study population was 71 [68-75]. The prevalence of current osteoporotic fractures was 22.3%. Osteoporosis was identified in 89.1% of participants, with 53.2% at the lumbar spine and 63.8% at the femoral neck. The area under the receiver operating characteristic curve (AUC) of the GARVAN model was higher than that of the FRAX model for both 10-year major osteoporotic fracture risk (0.789 vs. 0.742) and 10-year hip fracture risk (0.759 vs. 0.713); however, these differences were not statistically significant (DeLong test, p > 0.05).

Conclusions: Postmenopausal women with type 2 diabetes mellitus exhibited a relatively high prevalence of osteoporotic fractures. Both the FRAX and GARVAN models demonstrated comparable discriminative performance and were able to identify individuals with current fractures in this study population.

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