Articles Vol. 67 No. CĐ4-HN Ký sinh trùng-HN Hóa sinh 2026 21/04/2026

ASSIGNED VALUES AND Z-SCORES OF EXTERNAL QUALITY ASSESSMENT SAMPLES FOR COAGULATION TESTING ACROSS MULTIPLE PLATFORMS

Vo Ngoc Nguyen1,2, Vu Dinh Dung1,2, Nguyen Thi Hong Phuong1,2, Vu Dinh Dung1,2, Nguyen Ngoc Cuong1,2, Khang Bao Khanh1,2, Nguyen Thi Truc Linh1,2
1 Center for Standardization and Quality Control in Medical Laboratory of Ho Chi Minh city
2 Trung tâm Kiểm chuẩn xét nghiệm thành phố Hồ Chí Minh
DOI: 10.52163/yhc.v67iCD4.4850
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Keywords
External quality assessment, quality assurance, coagulation testing, assigned value, Z-score.
Abstract

Objectives: To determine the assigned values and evaluate the Z-score performance of laboratories participating in an external quality assessment pilot study for coagulation testing.

Methods: Coagulation external quality assessment samples at 3 concentration levels were produced and distributed to 67 participating laboratories in Ho Chi Minh city, Hue, and the Mekong Delta region. Robust statistical methods, in accordance with ISO 13528:2022, were employed to establish assigned values for PT, APTT, and fibrinogen based on participant data. The study further assessed the percentage of laboratories achieving acceptable Z-score across three major instrument platforms: Sysmex CS series, Stago Compact Max, and ACL TOP series.

Results: The assigned values for PT and APTT exhibited variations exceeding 10%, primarily due to methodological discrepancies between different instrumentation platforms. Regarding Z-score performance, 100% of laboratories achieved acceptable scores for fibrinogen, while the success rates for APTT and PT were over 85% and 70%, respectively.

Conclusions: This study provides a comprehensive overview of the current status of laboratory performance, serving as a basis for quality monitoring, training, and continuous improvement. The findings establish a significant foundation for the broader implementation of coagulation external quality assessment programs in the near future.

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