Articles Vol. 63 No. chuyên đề 2-HN Y học Giới tính (2022) 18/11/2022

SOME DISODERS OF SEX DEVELOPMENT DIAGNOSED AT VIETDUC UNIVERSITY HOSPITAL FROM 2015 TO 2022

Tran Thi Ngoc Anh1,2, Tran Thi Chi Mai3,4, Nguyen Viet Hoa1,2, Nguyen Quang1,2
1 Viet Duc University Hospital
2 Bệnh viện Hữu Nghị Việt Đức
3 Hanoi Medical University
4 Trường Đại học Y Hà Nội
Corresponding author: ngocanhbm@gmail.com
DOI: 10.52163/yhc.v63i7.478
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Keywords
Disorders of sex development, 5α-reductase type 2 deficiency, congenital adrenal hyperplasia, androgen insensitivity syndrome.
Abstract

Backgroud: Disorders of sex development (DSDs) are a group of diseases caused by many
different causes, including DSDs due to anormal stage of sex organ differentiation and
hormon synthesis disorders. Objectives: All patients diagnosed DSDs at Vietduc university
hospital from 2015 to 2022. Materials and method: Cross-sectional descriptive study.
Results: 53 patients with DSDs include 25 patients with 5α-reductase type 2 deficiency,
15 patients with congenital adrenal hyperplasia, 3 patients with androgen insensitivity
syndrome, 5 patient with complete gonadal dysgenesis, 1 patient with MRKH syndrome, 4
patients with Ovotesticular. Conclusions: At Vietduc university hospital, we are diagnosed
some causes DSDs. In woman, DSDs most common were congenital adrenal hyperplasia,
Mayer Rokitansky Kuster Hauser syndrome was rare in 46,XX patient. Enzyme 5α-reductase
type 2 deficiency, androgen insensitivity syndrome cause DSDs in man with pure 46,XY.
Ovotesticular and complete gonadal dysgenesis cause many cases DSDs both men and
women.

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