Articles Vol. 67 No. CĐ3-NCKH 02/04/2026

CHARACTERISTICS OF ANTIBIOTIC SKIN TESTS IN PATIENTS WITH A HISTORY OF ALLERGIES AT THE CLINICAL ALLERGY AND IMMUNOLOGY CENTER, BACH MAI HOSPITAL

Nguyen Nhu Nguyet1,2, Chu Chi Hieu1,2, Vu Thi Hang1,2, Bui Van Khanh1,2, Dinh Thi Dieu Tu3,4, Do Thi Tung Lam5,6, Nguyen Ngoc Anh7,8, Nguyen Thi Huyen Thuong7,8, Nguyen Thuy Linh7,8
1 Allergy Center – MDLS, Bach Mai Hospital
2 Trung tâm Dị ứng – MDLS, Bệnh viện Bạch Mai
3 General Planning Department, Bach Mai Hospital
4 Phòng Kế hoạch tổng hợp, Bệnh viện Bạch Mai
5 Tam Anh Hospital
6 Bệnh viện Tâm Anh
7 Hanoi Medical University
8 Đại học Y Hà Nội
DOI: 10.52163/yhc.v67iCD3.4731
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Keywords
allergy, skin prick test, intradermal test, antibiotic
Abstract

Objective: To describe the characteristics of antibiotic skin testing in patients with a history of allergy.

Methods: A prospective, cross-sectional descriptive study was conducted in patients with a history of allergy who attended the Allergen Clinic of the Center for Allergy and Clinical Immunology from January to March 2025.

Results: The study included 872 patients who underwent a total of 5,195 skin tests, comprising 4,875 skin prick tests (93.8%) and 320 intradermal tests (6.2%). Only 55 patients had positive skin test results to at least one antibiotic (44 skin prick tests and 11 intradermal tests). The highest rate of positive skin tests was observed in the quinolone group, whereas penicillins, carbapenems, tetracyclines, and lincosamides showed the lowest positivity rates. No cross-reactivity between antibiotics was detected.

Conclusion: Most antibiotic skin tests in patients with a history of allergy were negative; therefore, a general history of allergy may not be a risk factor for IgE-mediated antibiotic allergy.

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